Film-shaped, dissolvable preparations for active substance release and method for the production thereof

A preparation and film technology, applied in the field of preparation of this preparation, can solve the problems such as the reduction of the disintegration rate, and achieve the effect of improving the taste

Inactive Publication Date: 2005-08-24
LTS LOHMANN THERAPIE-SYST AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the disintegration rate decreases with increasing layer thickness

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0055] The present invention is illustrated by the examples in the following detailed description:

[0056] Numbering.

components

Dry matter ratio (wt%)

1

ethanol

2

pvp

33％

3

citric acid

20％

4

NaHCO3

35％

5

Menthol

7％

6

aspartame

5％

[0057] serial number

components

Dry matter ratio (wt%)

1

ethanol

2

HPC

33％

3

citric acid

20％

4

NaHCO 3

30％

5

Lemon Spice

12％

6

aspartame

5％

[0058] Preparation of mixtures in Examples 1 and 2:

[0059] The substance No. 1 was provided first, and then the substance No. 2 was added thereto while stirring to obtain a 15% polymer solution. Subsequently, Nos. 3, 5 and 6 were added and stirred until the mixture was homogeneous, after which ...

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Abstract

The invention relates to a film-shaped preparation which is dissolvable in an aqueous media and is used to administer substances into the human or animal body. Said preparation contains at least one water-soluble polymer. The invention is characterised in that the preparation contains one or several components which produce a gas under the effect of humidity or in the presence of an aqueous medium or when high temperature modifications occur.

Description

technical field [0001] The present invention relates to film-shaped preparations which are disintegrable in an aqueous medium and which are produced on the basis of water-soluble polymers and which can be used to administer substances to the human or animal body. The invention further relates to a process for the preparation of this formulation, as well as its use as a dosage form for pharmaceutical administration. Background technique [0002] Flat dosage forms, especially oral dosage forms, which disintegrate in an aqueous environment and enable rapid release of active substances in the oral cavity or other orifices or cavities of the body are known. For example, such dosage forms may be presented in "wafer" form. Due to their relatively thin layer thicknesses and disintegratability or solubility, these film-shaped flat administration forms are especially suitable for the rapid release of drugs or other active substances in the oral cavity. [0003] Flat wafer-like films...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K9/00A61K9/26A61K9/46A61K9/50A61K47/00A61K47/10
CPCA61K9/7007A61K9/0036A61K9/0007A61K9/00A61K9/20
Inventor 克瑞斯蒂娜·万·弗克豪森弗兰克·塞博特斯马克思·克儒姆
Owner LTS LOHMANN THERAPIE-SYST AG
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