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Application of effective part of chrysanthemum flower

An effective part, the technology of chrysanthemum, applied in the field of application of the effective part of chrysanthemum in the preparation of drugs for the treatment of ischemic heart disease, can solve problems such as limitations, and achieve the effects of reduced hygroscopicity, safe use, and less dosage

Inactive Publication Date: 2005-08-31
ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, existing data mostly use compound prescriptions as medicine when utilizing chrysanthemum, such as chrysanthemum leech soup [1] , silver chrysanthemum drink [2] etc., when the literature uses chrysanthemum alone, it also uses its total extract [3，4] However, due to the complex composition of the chrysanthemum total extract, the preparations made inevitably have the disadvantages of being thick, large, and black, and the total extract also has greater hygroscopicity because it contains more sugars, which limits the The choice of its dosage form

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0013] Example 1. Effect of effective parts of chrysanthemum on myocardial ischemia caused by canine coronary artery ligation

[0014] Beagle dogs, half male and half female, age 1-2 years old, body weight 8-10kg, are randomly divided into 6 groups, the dosage of each dog is calculated according to body weight, and the "0" capsule is put into the dog for consumption. Animal grouping and drug administration are as follows:

[0015] (1) Blank control group: feeding with blank capsules for 7 days, and giving 10 ml of normal saline via duodenum before operation.

[0016] (2) Model control group: feeding with blank capsules for 7 days, and giving 10 ml of normal saline through the duodenum before operation.

[0017] (3) Low-dose group: 17 mg / kg / day of the effective part of chrysanthemum was given for 7 days, and 17 mg / kg of the effective part of chrysanthemum was administered through the duodenum before operation.

[0018] (4) Medium-dose group: 34 mg / kg / day of the effective part...

example 2

[0034] Example 2. Effect of effective parts of chrysanthemum on myocardial ischemia in coronary artery ligation rats

[0035] SD rats, weighing 220-250g, male and female, were randomly divided into 6 groups:

[0036] (1) Blank control group: 2 ml of solvent was given by gavage for 7 days, and 2 ml of solvent was given by gavage before operation.

[0037] (2) Model control group: 2ml of solvent was given by intragastric administration for 7 days, and 2ml of solvent was administered by intragastric administration before operation.

[0038] (3) Low-dose effective part of chrysanthemum group: 50 mg / kg body weight of the effective part of chrysanthemum was given by gavage for 7 days, and 50 mg / kg body weight of the effective part of chrysanthemum was given by intragastric gavage before operation.

[0039] (4) Medium-dose effective part of chrysanthemum group: 100 mg / kg body weight of the effective part of chrysanthemum was administered orally for 7 days, and 100 mg / kg body weight ...

example 3

[0051] Example 3. Effects of effective parts of chrysanthemum on ST-T changes in ischemic myocardium induced by pituitrin

[0052] SD rats, body weight 220~250g, half male and half male, were randomly divided into 6 groups, and the treatment method of each group was the same as that of Example 2.

[0053] Experimental method: After the rats were anesthetized and fixed, the needle electrodes were inserted into the skin, and the standard II-lead ECG was recorded. If there is arrhythmia before the experiment, the animal is discarded. Inject vasopressin 0.6u / kg via the sublingual vein, finish within 5s. The electrocardiogram was recorded continuously for 30 minutes, and the ST-T changes of the electrocardiogram were analyzed. The results are shown in Table 6.

[0054] The results in Table 6 show that compared with the pituitrin model group, 10s and 15s after the injection of pituitrin, three doses of the active part of chrysanthemum group and the positive drug Ginkgo biloba ext...

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PUM

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Abstract

An application of the active components extracted from chrysanthemum flower in preparing the medicines in the form of solid or liquid for treating the ischemic heart disease is disclosed.

Description

technical field [0001] The invention belongs to the use of natural medicines, and relates to the application of the effective part of chrysanthemum, in particular to the application of the effective part of chrysanthemum in preparing medicine for treating ischemic heart disease. Background technique [0002] In the past 20 years, the incidence of coronary heart disease in my country has been on the rise, and the risk factors of cardiovascular disease in most people have also shown a continuous and rapid upward trend.” The patients are getting younger and younger, and the average age is close to 40 years old. The morbidity and mortality of cardiovascular diseases in western developed countries are even higher, becoming the number one killer that threatens health. Due to tissue damage caused by myocardial ischemia and hypoxia, survivors often have sequelae after the disease, seriously affecting patients Therefore, it is the common wish of international biomedical scientists and ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/20A61K9/48A61P9/10
Inventor 蒋惠娣夏强曾苏王如伟陈忆庭
Owner ZHEJIANG UNIV
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