Method for elementary separating 10-noracetyl Baccatins III from branches and leaves of yew

Abstract

A process for primarily extracting 10-deacetyl palcatine C from the twig and leaf of enqlish yew includes extracting in alcohol solution, concentrating laying aside, deposing taxol and low-polarity impurities, filtering, regulating pH=5-6, macroreticular resin adsorbing, eluting with absolute alcohol, and concentrating.

Description

technical field

[0001] The invention relates to a method for extracting plant components of yew, in particular to a method for primary separation of 10-deacetylbaccatin III from branches and leaves of yew with macroporous adsorption resin. Background technique

[0002] 10-Deacetylbaccatin III (10-DABIII) is a homologue of the anticancer drug Taxol (Taxol), and is also a precursor component of Taxol synthesized in plants. Now it is used as the precursor raw material of artificial semi-synthetic paclitaxel or docetaxel. Paclitaxel or docetaxel has been clinically used in the treatment of breast cancer, ovarian cancer, lung cancer, etc. It has good curative effect and small side effects, and is a newcomer in today's anticancer drugs. Our country and many countries in the world have approved production and clinical use, and the demand is increasing day by day. In the past, taxol was mainly derived from the bark of natural yew, and yew plants are rare and protected plants in th...