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Mri/nmr compatible hyperpolarized gas delivery valves for ventilators and associated gas delivery methods

A delivery valve, hyperpolarization technology, used in magnetic resonance measurements, respiratory protection devices, valve operation/release devices, etc., can solve problems such as slow reaction time

Inactive Publication Date: 2006-03-29
MEDI PHYSICS IN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Unfortunately, valves used to control the delivery of polarized gases have historically suffered from slow response times, relatively limited flow rates, and / or limited breathing rates (approximately 120 breaths per minute (BPM)). one or more constraints

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  • Mri/nmr compatible hyperpolarized gas delivery valves for ventilators and associated gas delivery methods
  • Mri/nmr compatible hyperpolarized gas delivery valves for ventilators and associated gas delivery methods
  • Mri/nmr compatible hyperpolarized gas delivery valves for ventilators and associated gas delivery methods

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Embodiment Construction

[0028] The present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which preferred embodiments of the invention are shown. However, this invention may be embodied in many different forms and should not be construed as limited to the embodiments described herein. Like numbers refer to like elements throughout. In the drawings, layers, regions or components may be exaggerated for clarity. In the figures, dashed lines indicate optional features unless otherwise described.

[0029] In the ensuing description of the invention, certain terms may be used to indicate the positional relationship of some structures relative to other structures. As used herein, the term "forward" and its derivatives indicate the general direction of travel of the target gas or target gas mixture as it moves through the superifier system; this term is synonymous with the term "downstream", the term " "Downstream" is often used in the context of man...

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Abstract

Methods, systems, assemblies, computer program products and devices deliver hyperpolarized gas by: (a) providing a gas delivery valve with at least one gas flow path therein, the valve comprising a valve body and at least one spool held in the valve body; (b) transmitting a pilot command fluid pulse signal to the at least one spool to introduce pressure onto the spool to force the spool to translate an actuation distance in the valve body; and (c) opening and / or closing the at least one gas flow path in response to the transmitted signal to deliver hyperpolarized gas to a subject.

Description

technical field [0001] The present invention relates to the delivery of polarized noble gases to a subject for evaluation using NMR spectroscopy and / or magnetic resonance imaging ("MRI"). Background technique [0002] Polarized inert noble gases can produce improved MRI images of certain areas and regions of the body that previously produced unsatisfactory images with this method. It has been found that polarized helium-3 (“ 3 He") and Xenon-129 (" 129 Xe") are particularly suitable for this purpose. Unfortunately, the polarization state of gases is sensitive to handling and environmental conditions, and can undesirably decay from a polarization state relatively quickly. [0003] Hyperpolarizers are used to produce and accumulate polarized noble gases. Hyperpolarizers artificially enhance certain noble gas nuclei (such as 129 Xe or 3 He) polarization beyond the natural or equilibrium level, known as Boltzmann polarization. Such an increase is desirable because it enhan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/28
CPCF16K11/0712A62B9/02G01R33/28G01R33/5601F16K31/122A61B5/055
Inventor K·博拉姆J·戴维逊J·博尔根
Owner MEDI PHYSICS IN