Tissue engineering bone containing innervation and its construction
A tissue-engineered bone and nerve innervation technology, applied in the direction of bone/connective tissue cells, bone implants, medical science, etc., can solve the problem that no one is exploring, and achieve fast repair speed, good repair effect, and simple operation. Effect
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[0028] The tissue engineered bone containing innervation of the present invention, such as figure 1 As shown, it includes a carrier scaffold 1 and a seed cell 2. The seed cell 2 is attached to the carrier scaffold 1 to form a complex with a three-dimensional structure of bone tissue and biological activity. The carrier scaffold 1 is a biodegradable material containing innervation , the innervation is to implant the sensory nerve bundle 3 in the carrier bracket; the seed cells 2 are bone marrow stromal stem cells (BMSc), and the bone marrow stromal stem cells are taken from autologous bone marrow, separated and expanded to cell Density is 10 6 -10 7 pieces / ml.
[0029] Such as figure 2 As shown, the innervation is combined implantation of sensory nerve bundle 3 and motor nerve bundle 4 in carrier bracket 1 .
[0030] Such as image 3 and Figure 4 As shown, the tissue engineered bone complex is also implanted with a vascular bundle 5 .
[0031] The biodegradable materia...
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