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Composition for preventing and treating hepatoma

A composition and technology for liver cancer, applied in the directions of drug combination, medical raw materials derived from gymnosperm subphylum, application, etc., can solve the problem of no research report on liver cancer, achieve high liver cancer proliferation inhibition effect, and improve the effect of abnormal metabolism

Inactive Publication Date: 2007-01-10
NOKODAI TLO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research report on the effect of lignans on liver cancer so far.

Method used

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  • Composition for preventing and treating hepatoma
  • Composition for preventing and treating hepatoma
  • Composition for preventing and treating hepatoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] In this example, in order to analyze the effect of ENL on the proliferation and invasion of liver cancer cells (in vitro / in vitro), the anti-tumor effect of ENL on AH109A cells was studied.

[0037] 1. Materials and Methods

[0038] (1) Material

[0039] The chemical structural formula of ENL used in this embodiment is shown in Formula 1.

[0040]

[0041] (2) Culture of liver cancer cells

[0042] Rat ascites liver cancer AH109A cells (Tohoku University Institute of Aging Medicine (Sendai)) were maintained by serial transplantation into the abdominal cavity of Donryu male rats (NRC Haruna, Gunma). When rat ascites was sufficiently accumulated, AH109A cells were purified from ascites. After centrifuging ascitic fluid at 1000rpm (190×g) and 4°C for 10 minutes, remove the supernatant, add an equal amount of hemolysis buffer [0.16M NH 4 Cl: 0.17M Tris (trishydroxymethylaminomethane) = 9: 1, pH 7.2 (all purchased from Wako Pure Chemical Industries, Osaka, Japan)], af...

Embodiment 2

[0069] In this example, in order to analyze the effects of ENL on cancer proliferation, metastasis, and hyperlipidemia during liver cancer transplantation (in vivo), rats were actually ingested with ENL, and the effect on cancer proliferation in a cancer-bearing rat model was analyzed. , metastasis, and cancer cachexia.

[0070] 1. Materials and Methods

[0071] (1) Animal feeding

[0072] After purchasing 4-week-old Donryu male rats (NRC Haruna, Gunma), five consecutive cages, lighting period 8:00-20:00, room temperature 22 ± 1 ° C, relative humidity 60 ± 5% of the environmental control room, Preliminary feeding was carried out for 6 days. A solid feed (CE-2; CLEA Japan, Tokyo) was added to the glass containers for the first 3 days, and a basal feed (20C) (Table 1) containing 20% ​​casein protein was added to the glass containers for the next 3 days. They were given free access to tap water. After the preparatory feeding, the weights of each group were divided into 3 grou...

Embodiment 3

[0118] A composition for the prevention and treatment of liver cancer is produced by formulating enterolactone (ENL) as an active ingredient and a pharmacologically acceptable carrier component in a predetermined amount, and formulating them.

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PUM

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Abstract

It is intended to provide a composition for preventing and treating hepatoma. Namely, a composition for preventing and treating hepatoma characterized by containing, as the active ingredient, enterolactone (ENL) or a compound which is its plant lignan precursor and has an effect of inhibiting the growth of hepatoma; a drug for preventing and treating hepatoma characterized by comprising enterolactone (ENL) or a compound which is its plant lignan precursor and has an effect of inhibiting the growth of hepatoma together with a pharmaceutically acceptable carrier; and a functional food material characterized in that enterolactone (ENL) or a compound which is its plant lignan precursor and has an effect of inhibiting the growth of hepatoma is blended, as the functional component, with a food material.

Description

technical field [0001] The present invention relates to a novel composition for the prevention and treatment of liver cancer, and more specifically, to a drug for the prevention and treatment of liver cancer containing enterolactone (ENL) or its plant lignan precursor as an active ingredient, and a drug for the prevention and treatment of liver cancer containing these ingredients as a functional Functional food with active ingredients. The present invention can be used in the technical field of pharmaceuticals for the prevention and treatment of liver cancer and functional foods related thereto to provide an in-situ product utilizing lignans widely present in roots, leaves, stems, seeds, fruits, etc. of plants. Enterolactone (ENL), the main metabolite in mammals, has a strong inhibitory effect on the proliferation of liver cancer, a new type of liver cancer prevention and treatment drug, cancer treatment agent, and new functional food. Background technique [0002] Lignan i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P35/00A23L1/30C07D307/32A61K36/15C07D307/33
CPCC07D307/33A23V2002/00A61K31/365A61K36/15A23L1/3002A23L33/105A61P35/00A23V2200/308A23V2250/21
Inventor 矢崎一三三浦丰三浦大树里斯托·桑迪尼纳·萨利南
Owner NOKODAI TLO KK
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