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Composition for inhibiting phosphorus absorption

A composition, phosphorus absorption technology, applied in the direction of drug combination, application, dairy products, etc., to achieve the effects of excellent safety, disease improvement, and excellent taste

Active Publication Date: 2021-03-19
MEIJI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports of the effects on bone strength of long-term subcutaneous administration of PPIs in humans or animals

Method used

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  • Composition for inhibiting phosphorus absorption
  • Composition for inhibiting phosphorus absorption
  • Composition for inhibiting phosphorus absorption

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0079] 1. Test materials and test methods

[0080] 1.1. Feed

[0081] In fermented milk, lactic acid bacteria (Lactobacillus bulgaricus and Streptococcus thermophilus isolated from Meiji Bulgaria plain yogurt) were cultured using skim milk as a medium, and the obtained culture was freeze-dried . Then, this freeze-dried fermented milk was subjected to electron beam sterilization at 10-kGy to prepare (manufacture). On the other hand, in the galacto-oligosaccharide (GOS) raw material (Cup-Oligo), the content of GOS was 73 weight%.

[0082] AIN93M (content of Ca: 0.5% by weight, content of phosphorus: 0.3% by weight) was used as a control diet. The test food (YG food) which fermented milk and GOS raw material used the freeze-dried product of fermented milk which substituted part of casein, and used GOS which substituted part (5 weight%) of sucrose. At this time, the control diet and the test diet (YG diet) were adjusted so that the concentrations of Ca, phosphorus, and crude p...

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Abstract

Provided is a composition for limiting phosphorous absorption, the composition including a fermented dairy product and a galactooligosaccharide. Further provided is a composition for treating and / or preventing disease caused by the excessive intake of phosphorous, the composition including a fermented dairy product and a galactooligosaccharide.

Description

technical field [0001] The present invention relates to a composition for inhibiting phosphorus absorption comprising fermented dairy products and oligosaccharides as active ingredients. In addition, the present invention also relates to a composition for treating or preventing diseases caused by excessive intake of phosphorus, or both, containing fermented milk products and oligosaccharides as active ingredients. Background technique [0002] Proton pump inhibitors (PPIs), which are powerful gastric acid secretion inhibitors, are one of the most widely used oral drugs in the world, and are generally considered safe. On the other hand, there have been reports of an increased fracture risk when using PPIs. In contrast, the present inventors reported that short-term subcutaneous administration of PPI to growing rats reduced bone mineral density (BMD) and bone strength (Non-Patent Document 1, Non-Patent Document 2). However, there is no report on the effect on bone strength o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23C9/13A23C19/076A23L33/10A61K31/702A61K35/20A61P19/08
CPCA23C9/13A23C19/076A61K31/702A61K35/20A23L33/10
Inventor 高杉谕圷美穗北出晶美长田昌士
Owner MEIJI CO LTD
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