Biological degradable nano medicinal capsule with MRI tracer effect and its preparing method

A technology of biodegradation and nano-drugs, applied in medical preparations containing active ingredients, drug delivery, capsule delivery, etc., can solve the problems of single imaging parameters and inflexibility, and achieve simple process, high drug loading capacity, and production equipment less demanding effect

Inactive Publication Date: 2007-04-11
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These methods have a single im...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Take 3ml of 3.5% (w / v) aqueous solution of polyethylene glycol PEG as the inner water phase (i.e. dispersion system A), disperse 30mg ovalbumin and 0.8mg NMG2[Gd-DTPA·H2O] (trade name Magnevist) In water; the organic phase (i.e. dispersion system B) is 6ml dichloromethane dissolved with 2.5% (w / v) PLGA; the external aqueous phase (i.e. dispersion system C) is 0.4% (w / v) PEG54ml stirred and dissolved aqueous solution. Add the inner water phase to the organic phase and disperse it evenly in a homogenizer (9500rpm), then add it to the outer water phase to disperse, at a temperature of 23°C and a pressure of 1.01×10 5 Under Pascal conditions, stir until the organic phase is completely evaporated, PLGA precipitates and solidifies into balls, and ovalbumin and NMG2[Gd-DTPA·H2O] (trade name Magnevist) are coated inside to form a core / shell structure drug-loaded nanocapsules.

Embodiment 2

[0065] Get the aqueous solution of 4.5% (w / v) polyvinyl alcohol PVA of 3ml as internal water phase, 45 milligrams of doxorubicin and 1.2mg NMG2 [Gd-DTPA · H O] (trade name Magnevist) are dispersed in water; There are 6ml of acetone with 6% (w / v) PLA; the external aqueous phase is 65ml aqueous solution of 0.5% (w / v) PVA dissolved by stirring. Add the inner water phase to the organic phase and disperse it evenly in the disperser (9500rpm), and then add it to the outer water phase to disperse. 5 Under the condition of Pascal, stirring and evaporating for about 180 minutes to remove the organic phase, PLA precipitated and solidified into spheres, and doxorubicin and NMG2[Gd-DTPA·H2O] (trade name Magnevist) were coated inside to form a core / shell structure. drug nanocapsules.

Embodiment 3

[0067] Get 6ml of 5% (w / v) sodium dodecylsulfonate aqueous solution as the inner water phase, 30 mg paclitaxel and 1.5 mg NMG [Gd-DTPA H O] (trade name Magnevist) are dispersed in water; the organic phase is 6 ml of dichloromethane dissolved with 10% (w / v) PLGA; the external aqueous phase is 54 ml of 0.4% (w / v) PVA aqueous solution dissolved by stirring. Add the inner water phase to the organic phase and disperse it evenly in a mixer (9500rpm), then add it to the outer water phase to disperse at a temperature of 26. ℃, pressure 1.01×10 5 Pa, stirred and evaporated for about 240 minutes to remove the organic phase, PLGA precipitated and solidified into balls, and paclitaxel and NMG2[Gd-DTPA·H2O] (trade name Magnevist) were coated inside to form drug-loaded nanocapsules with a core / shell structure.

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Abstract

A biodegradation nanometer medicine capsule with MRI trace effect and its preparation method is presented, said capsule measurement is nanometer and its structure is of nuclear/ shell, shell layer consists of biodegradation high polymer, nuclear layer consists of MRI radiography agent and hydrophilic or water-soluble drug. Said capsule featuring multiple effect function, demonstration of high entrapment, application of targeting and controlled delivering, application of vitro timely controlling by MRI, etc. provides an effective medicine carrier.

Description

technical field [0001] The invention relates to a nano-medicine capsule, in particular to a biodegradable multi-effect nano-medicine capsule with MRI trace effect and real-time monitoring of drugs in vitro and a preparation method thereof. Background technique [0002] As we all know, the study of nano-drugs is a very promising new direction in drug research. Drugs are mainly loaded into nano-drug carriers by encapsulation and adsorption. Nanotechnology has been used in drug research. Many years of work have been carried out abroad. The particle size range is wide, mostly 100-1000nm, which are called nanoparticles (nanospheres and nanocapsules), and the larger ones are called microcapsules or nanocapsules. Microspheres. Since the particle size of nano-medicine is smaller than the capillary diameter (6-8 μm), it can easily enter various tissues and organs of the human body for controlled release, greatly improving the bioavailability of the drug. It also has many advantages...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K45/06A61K49/06A61K49/18
Inventor 任山陈卫丰崔秀环洪澜冉丕鑫刘志刚李立曾木圣
Owner SUN YAT SEN UNIV
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