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Traditional Chinese medicinal compound preparation for treating asthma and its preparation method

A compound preparation and a technology for asthma, applied in the field of traditional Chinese medicine compound preparations, can solve the problems of patients unable to effectively prevent recurrence, unsatisfactory effect, and only pay attention to relieving asthma, so as to improve the dynamic compliance of the lung, reduce the release of inflammatory mediators, and reduce the Effects of Airway Inflammation

Inactive Publication Date: 2007-05-02
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern medicine believes that asthma is a chronic airway inflammation involving eosinophils, mast cells, T lymphocytes and other inflammatory cells. Therefore, Western medicine treatment mainly focuses on anti-inflammatory and antispasmodic agents. The market mainly uses corticosteroid inhalants. , adrenaline inhalers, other asthma inhalants, systemic epinephrine and other Western medicines are dominant. Although these drugs have a relatively rapid effect and are easy to relieve symptoms in patients with acute attacks, they "only treat the symptoms, not the root cause". Only pay attention to asthma relief, but chronic eosinophilic bronchial inflammation, which is the root cause of asthma recurrence, has not been eliminated. As long as an allergen is encountered at any time, asthma will definitely be induced, and the relapse cannot be effectively prevented for patients in the remission period, so the effect is not ideal and there is a certain risk. side effects of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Example 1: 1 part of Epimedium, 1 part of Morinda officinalis, 1 part of Huhuanglian

[0106] Take Epimedium medicinal material, add 10 times the volume of 70% ethanol to reflux and extract 3 times, each time for 1 hour, combine the extracts, recover the ethanol under reduced pressure and measure the relative density to 1.05-1.15 at 60°C, add water 4 times the volume of the medicinal material Dissolve, filter, and pass the filtrate through the polyamide column at a speed of 0.5ml / g medicinal material.min, wash the impurities with water 7 times the volume of polyamide in turn, then desorb with 60% ethanol 5 times the volume of polyamide, collect the desorption liquid, and decompress When recovering ethanol to 60°C, the measured relative density is 1.05 to 1.15, and dried to obtain Epimedium extract; take Morinda officinalis medicinal material, add 8 times the volume of 70% ethanol to reflux and extract 3 times, each time for 1 hour, combine the extracts, reduce When the ...

Embodiment 2

[0107] Example 2: 1 part of Epimedium, 99 parts of Morinda officinalis, 1 part of Huhuanglian

[0108] Take Epimedium medicinal material, add 10 times the volume of 70% ethanol to reflux and extract 3 times, each time for 2.0 hours, combine the extracts, recover the ethanol under reduced pressure and measure the relative density to 1.05-1.15 at 60°C, add water 3 times the volume of the medicinal material Dissolve, filter, pass the filtrate through the polyamide column at a speed of 0.8ml / g medicinal material.min, wash the impurities with 5 times the volume of polyamide water in turn, then desorb with 50% ethanol 6 times the volume of polyamide, collect the desorption liquid, and recover under reduced pressure When the ethanol reaches 60°C, the relative density is 1.05-1.15, and dried to obtain the epimedium extract; take the Morinda officinalis medicinal material, add 12 times the volume of 70% ethanol to reflux and extract 3 times, each time for 2.0 hours, combine the extracts...

Embodiment 3

[0109] Embodiment 3: 50 parts of Epimedium, 50 parts of Morinda officinalis, 50 parts of Hu Huanglian

[0110] Take Epimedium medicinal material, add 15 times the volume of 80% ethanol to reflux and extract 3 times, each time for 1.5 hours, combine the extracts, recover the ethanol under reduced pressure and measure the relative density to 1.05-1.15 at 60°C, add 4 times the volume of the medicinal material in water Dissolve, filter, pass the filtrate through the polyamide column at a speed of 0.8ml / g medicinal material.min, wash the impurities with 5 times the volume of polyamide water in turn, then desorb with 50% ethanol 6 times the volume of polyamide, collect the desorption liquid, and recover under reduced pressure When the ethanol reaches 60°C, the relative density is 1.05-1.15, and dried to obtain Epimedium extract; take Morinda officinalis medicinal material, add 12 times the volume of 60% ethanol to reflux and extract 3 times, each time for 2.0 hours, combine the extra...

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Abstract

A composite medicine in the form of injection or orally taken solid or liquid for treating asthmatic chronic bronchitis, acute bronchal asthma, lung infection, pneumonia, pneumonectasis, cardiogenic asthma, pulmonary tuberculosis, silicosis, etc is prepared from epimedium or its extract, picrorhiza rhizome or its extract, and indianmulberry root or its extract. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation for treating asthma, and provides a preparation method of the compound preparation, which belongs to the technical field of traditional Chinese medicine. technical background [0002] Asthma is a global, one of the most common clinical chronic diseases that are difficult to cure and prone to repeated attacks. There are about 160 million patients in the world. Survey reports from several foreign countries indicate that the prevalence of asthma in children is 0.2% to 7.4%, and the prevalence of asthma in adults is 1.1% to 9.9%. The prevalence of asthma in my country is about 0.5% to 2.0% according to local area surveys, and it has also been reported as high as 5.29%. Asthma can occur at any age and affects men and women roughly equally in adults. With the continuous improvement of the degree of industrialization, due to the aggravation of air pollution and the development of c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/80A61K9/00A61P11/06
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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