Methods of modulating a mammalian cytokine

a technology of cytokine and mammalian cytokine, which is applied in the direction of dna/rna fragmentation, peptide/protein ingredients, depsipeptides, etc., can solve the problems of disease that strikes about 1% of the population and cannot be cured, and achieves the effects of increasing the count of total white blood cells, increasing platelet counts, and modulating blood cell counts
US20070160579A1Inactive Publication Date: 2007-07-12MERCK SHARP & DOHME CORP
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
MERCK SHARP & DOHME CORP
Publication Date
2007-07-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.
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Description

[0001] This filing is a U.S. Patent Application which claims benefit of U.S. Provisional Patent Application No. 60 / 545,730, filed Feb. 17, 2004, which is incorporated herein by reference.FIELD OF THE INVENTION

[0002] The present invention relates generally to uses of mammalian cytokines. More specifically, the invention discloses methods of using IL-33, and a receptor for IL-33. BACKGROUND OF THE INVENTION

[0003] The immune system protects individuals from infective agents, e.g., bacteria, multi-cellular organisms, as well as cancers. This system includes several types of lymphoid and myeloid cells such as monocytes, macrophages, dendritic cells (DCs), eosinophils, T cells, B cells, and neutrophils. These lymphoid and myeloid cells often produce signaling proteins known as cytokines. Immune response includes inflammation, i.e., the accumulation of immune cells systemically or in a particular location of the body. In response to an infective agent or foreign substance, immune cells s...

Claims

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