Naphthalimide compositions and uses thereof
a technology of naphthalimide and composition, which is applied in the direction of biocide, heterocyclic compound active ingredients, heavy metal active ingredients, etc., can solve the problems of cancer cell death, premature termination of dna chain, cell death,
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example 1
Chemopotentiation of Cisplatin by Amonafide
[0057] Transplantable experimental murine fibrosarcomas (2×105 RIF-1 cells) were grown intradermally in the flanks of 3 month old female C3H mice (Charles River, Holister, Calif.). When the tumors reached a volume of approximately 100 mm3, the mice were randomly assigned to each experimental group (4 mice per group).
[0058] The experimental compositions were prepared as described in Table 2.
TABLE 2AgentDoseSolventSupplierAmonafide50 mg / kgDMSONCICisplatin 4 mg / kgWater for injectionDavid Bull Labs
[0059] The chemopotentiator, amonafide, was obtained from NCI and was made to the appropriate concentration in DMSO. Cisplatin (David Bull Laboratories-Mulgrave, Australia, lot. 5201844x) was made to the appropriate concentration in water for injection. The compositions were injected systemically (i.e., intraperitoneally, i.p.), in a volume of 100 microliters. For the treatment of group 3, the chemopotentiator, amonafide, was injected 30 minutes ...
example 2
EFFECT OF AMONAFIDE, ALONE AND IN COMBINATION WITH OTHER CHEMOTHERAPEUTICS ON RIF-1 TUMOR GROWTH IN C3H MICE
[0063] The RIF-1 murine fibrosarcoma tumor model was used to evaluate the antitumor activity of amonafide, alone and in combination with various antiproliferative agents. The antiproliferative agents used include those that affect nucleic acid (e.g., DNA) integrity (e.g., cisplatin, etoposide, 5-fluorouracil), agents that affect structural or cytoplasmic proteins or their synthesis (e.g., homoharringtonine, paclitaxel, vinblastine, colchicine, curcumin or parthenolide).
[0064] Amonafide-NCI was obtained from NCI as a powder. Amonafide-Penta was obtained from Penta Biotech (Union City, Calif.), Lot No. 039-01, as a powder. Cisplatin for Injection, USP, was obtained from David Bull Labs (Mulgrave, Australia), Lot No. 5201844x, as a lypholized powder. Paclitaxel was obtained from Bristol Myers Squibb Co. (Princeton, N.J.), Lot No. 9J16241, exp. September 2001, prediluted to 6 mg / ...
example 3
Effect of Amonafide in Combination with Camptothecin, Genistein or Rosmarinic Acid on RIF-1 Tumor Growth in C3H Mice.
[0087] Transplantable experimental murine fibrosarcomas (2×105 RIF-1 cells) were grown intradermally in the flanks of 3 month old female C3H mice (Charles River, Holister, Calif.). When the tumors reached a volume of −100 mm3, the mice were randomly assigned to each experimental group (4 mice per group).
[0088] The experimental compositions were prepared as described in Table 6.
TABLE 6AgentDoseSolventSupplierAmonafide30mg / KgsalinePentaCamptothecin6mg / KgDM SOBoehingerIngelheimGenistein60mg / KgDMSOChemCon GmbHRosmarinic20DMSOTocrisAcid
[0089] Amonafide was manufactured by Penta for ChemGenex and was made to the appropriate concentration in saline. Genistein (ChemCon GmbH, Lot CC6700-26) Rosmarinic acid (Tocris-Batch 2 / 18077) and Camptotheicn (Boehinger Ingelheim-Lot 142088) were made to the appropriate concentrations in DMSO. The compositions were injected systemicall...
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