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Nutritional Composition Comprising Indigestible Oligosaccharides

a technology of indigestible oligosaccharides and nutritional compositions, which is applied in the direction of drug compositions, antibody medical ingredients, metabolic disorders, etc., can solve the problems of difficult treatment of respiratory infections, limited treatment options for established respiratory tract diseases, and serious respiratory tract diseases in infants and children, so as to reduce stress and reduce the occurrence of respiratory infections

Active Publication Date: 2008-05-29
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about a nutritional composition that reduces the occurrence of respiratory tract infections, particularly in infants. The composition contains a combination of two types of oligosaccharides: a galactose containing indigestible oligosaccharide and a digestible galactose saccharide. The invention is safe and can be added to nutrition, reducing stress for infants. The invention is particularly effective in preventing or treating respiratory infections caused by respiratory syncytical virus. The nutritional composition can also contain immunoglobulins with virus neutralizing activity.

Problems solved by technology

Treatment options for established RSV disease are limited.
Parainfluenza viral infection results in serious respiratory tract disease in infants and children.
Treatment of respiratory infection is often difficult.
Only a few effective drugs are available and often treatment requires pulmonary administration of the drug.
In young infants this leads to significant stress.

Method used

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  • Nutritional Composition Comprising Indigestible Oligosaccharides

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0065]

Packaged infant milk formula provided with a label indicatingthat the formula can be suitably used to prevent respiratorytract infection by respiratory syncytial virus formula containingper 100 ml final product (and per 13.1 g powder):8 energy % protein1.4g (casein whey mixture)45 energy % digestible carbohydrates7.5g47 energy % fat3.5gtransgalactooligosaccharides (TOS)0.3g

example 2

[0066]Packaged infant milk formula according to example 1, wherein the packaging is provided with a label indicating that the formula can be suitably used to reduce difficulty with breathing.

example 3

[0067]

Packaged infant milk formula according to example 1, furthercontaining per 100 ml final product (and per 13.1 g powder);Raftilin HP, Orafti BE)0.1gBifidobacterium breve:1.3 × 108cfutuna fish oil0.3gram40% arachidonic acid oil0.3gram(DSM Food Specialties, Delft, Netherlands)

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Abstract

The present invention provides a method and composition for the treatment and / or prevention of respiratory tract infection and / or respiratory tract infection disease, said method comprising orally administering a composition to a mammal, said composition comprising a galactose containing indigestible oligosaccharide and at least 5 wt. % digestible galactose saccharide.

Description

FIELD OF THE INVENTION[0001]The present invention provides a method for the prevention and / or treatment of respiratory tract infections, said method comprising the administration of indigestible oligosaccharides.BACKGROUND OF THE INVENTION[0002]The respiratory tract is a common site for infection by pathogens. It becomes infected frequently because it is in direct contact with the physical environment and is exposed to microorganisms in the air. There are several microorganisms that cause illness in infants.[0003]Respiratory syncytial virus (RSV) is the leading cause of serious lower respiratory tract disease in infants and children. Primary RSV infection occurs most often in children from 6 weeks to 2 years of age. RSV is estimated to cause as much as 75% of all childhood bronchiolitis and up to 40% of all pediatric pneumonias. Children at increased risk from RSV infection include preterm infants and children with bronchopulmonary dysplasia, congenital heart disease, congenital or ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/733A61K31/715A61K45/00A61K39/42A61P11/00A23L1/30A23L33/00A61K31/202A61K31/702A61K35/741
CPCA23L1/296A61K31/733A23L1/308A23V2002/00A23Y2300/29A61K31/202A61K31/702A61K35/741A61K39/42A23L1/3008A61K2300/00A23V2200/324A23V2250/28A23V2250/608A23V2250/304A23V2250/1642A23V2250/1882A23V2200/3202A23V2200/3204A23L33/40A23L33/12A61P1/00A61P11/00A61P25/00A61P3/02A61P3/10A61P31/00A61P31/12A61P31/14A61P31/18A23V2400/519A23L33/21
Inventor BOEHM, GUNTHERM'RABET, LAURASTAHL, BERNDGARSSEN, JOHAN
Owner NV NUTRICIA
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