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Molecules associated with cell proliferation

a technology of molecules and cell proliferation, applied in the field of nucleic acid and amino acid sequences of molecules associated with cell proliferation, can solve the problems of cell proliferation, reduced or lost function, etc., and achieve the effect of increasing expression or activity and reducing expression or activity

Inactive Publication Date: 2008-07-31
INCYTE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

Mutations which cause reduced or loss of function in tumor-suppressor genes result in cell proliferation.

Method used

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  • Molecules associated with cell proliferation

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I. Construction of cDNA Libraries

[0181]RNA was purchased from CLONTECH Laboratories, Inc. (Palo Alto, Calif.) or isolated from tissues described in Table 4. Some tissues were homogenized and lysed in guanidinium isothiocyanate, while others were homogenized and lysed in phenol or in a suitable mixture of denaturants, such as TRIZOL reagent (Life Technologies, Inc., Rockville, Md.), a monophasic solution of phenol and guanidine isothiocyanate. The resulting lysates were centrifuged over CsCl cushions or extracted with chloroform. RNA was precipitated from the lysates with either isopropanol or sodium acetate and ethanol, or by other routine methods.

[0182]Phenol extraction and precipitation of RNA were repeated as necessary to increase RNA purity. In some cases, RNA was treated with DNase. For most libraries, poly(A+) RNA was isolated using oligo d(T)-coupled paramagnetic particles (Promega Corp., Madison, Wis.), OLIGOTEX™ latex particles (QIAGEN Inc., Valencia, Calif.), or an OLIGOTE...

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Abstract

The invention provides human molecules associated with cell proliferation (MACP) and polynucleotides which identify and encode MACP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of MACP.

Description

TECHNICAL FIELD[0001]This invention relates to nucleic acid and amino acid sequences of molecules associated with cell proliferation and to the use of these sequences in the diagnosis, treatment, and prevention of cell proliferative and immune disorders.BACKGROUND OF THE INVENTION[0002]Tissue growth involves cell proliferation, differentiation, and apoptosis to generate functionally organized multicellular patterns. Cell proliferation has to be regulated so as to maintain both the number of cells and their spatial organization. This regulation depends on interactions of cells with one another and with the extracellular matrix. The molecules which provide this regulation fall into several categories, including growth factors, oncogenes, tumor-suppressor genes, as well as extracellular matrix and cell adhesion molecules.[0003]Growth factors were originally described as serum factors required to promote cell proliferation. Though growth factors are present in the circulation, most act ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07K16/18C07K14/435C12P21/00C12N15/09A61K38/00A61K45/00A61P35/00A61P37/02C07K14/47C07K14/52C07K16/22C12N1/15C12N1/19C12N1/21C12N5/10C12N15/12C12P21/02C12Q1/68
CPCC07K14/4702A61K38/00A61P35/00A61P37/02
Inventor TANG, Y. TOMLAL, PREETIHILLMAN, JENNIFER L.CORLEY, NEIL C.ARVIZU, CHANDRABAUGHN, MARIAH R.
Owner INCYTE CORP
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