Microcapsules having multiple shells and method for the preparation thereof

a microcapsule and shell technology, applied in the field of microcapsules having multiple shells, can solve the problems of high ratio of shell material to loading material, low payload of multi-core microcapsule, and unsatisfactory reduction of the loading capacity of the microcapsule, etc., and achieve the effect of strengthening the microcapsul

Inactive Publication Date: 2010-04-15
DSM NUTRITIONAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides a multi-core microcapsule and a single-core microcapsule with multiple shells that comprise a complex coacervate. The process for making the microcapsule involves mixing the microcapsule with polymer components in solution and adjusting pH, temperature, concentration, and mixing speed to form the additional shell. The technical effect of this invention is the improved stability and efficiency of the microcapsule in various applications such as drug delivery, cosmetics, and food and beverage industries.

Problems solved by technology

But this results in an undesirable reduction in the loading capacity of the microcapsule.
As a result, there is a high ratio of shell material to loading material and the payload of the multi-core microcapsule is therefore low.
Moreover, despite the high ratio of shell material to loading substance in such microcapsules, the shell material is poorly distributed.
The cores at the surface are therefore not well protected against rupture or from oxidation.
Known microcapsules therefore either have a poor payload, or fail to adequately contain and protect the loading substance deposited therein.
Moreover, because these microcapsules are generally prepared in a single step, it is difficult to incorporate multiple functionalities, such as oxidation resistance, moisture resistance and taste masking into a single microcapsule.

Method used

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  • Microcapsules having multiple shells and method for the preparation thereof
  • Microcapsules having multiple shells and method for the preparation thereof
  • Microcapsules having multiple shells and method for the preparation thereof

Examples

Experimental program
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Effect test

example 1

Multicore Microcapsules Prepared by One-Step Process for Comparison (both First and Second Shells having the Same Composition of Gelatine and Polyphosphate)

[0070]54.5 grams gelatine 275 Bloom type A (isoelectric point of about 9) was mixed with 600 grams of deionized water containing 0.5% sodium ascorbate under agitation at 50° C. until completely dissolved. 5.45 grams of sodium polyphosphate was dissolved in 104 grams of deionized water containing 0.5% sodium ascorbate. 90 grams of a fish oil concentrate containing 30% eicosapentaenoic acid ethyl ester (EPA) and 20% docosahexaenoic acid ethyl ester (DHA) (available from Ocean Nutrition Canada Ltd.) was dispersed with 1.0% of an antioxidant (mixed natural tocopherols) into the gelatine solution with a high speed Polytron™ homogenizer at 5,500 rpm for 6 minutes. An oil-in-water emulsion was formed. The oil droplet size had a narrow distribution with an average size of about 1 μm measured by Coulter™ LS230 Particle Size Analyzer. The ...

example 2

[0071]A Two-Step Process with Gelatine and Polyphosphate in both First and Second Shells, but having Different Compositions

[0072]Step A: 15.6 grams gelatine 275 Bloom type A (isoelectric point of about 9) was mixed with 172 grams of deionized water containing 0.5% sodium ascorbate under agitation at 50° C. until completely dissolved. 1.56 grams of sodium polyphosphate was dissolved in 29.7 grams of deionized water containing 0.5% sodium ascorbate. 69 grams of a fish oil concentrate containing 30% eicosapentaenoic acid ethyl ester (EPA) and 20% docosahexaenoic acid ethyl ester (DHA) (available from Ocean Nutrition Canada Ltd.) was dispersed with 1.0% of an antioxidant (mixed natural tocopherols) into the gelatine solution with a high speed Polytron™ homogenizer at 6,100 rpm for 4 minutes. An oil-in-water emulsion was formed. The oil droplet size had a narrow distribution with an average size of about 1 μm measured by Coulter™ LS230 Particle Size Analyzer. The emulsion was diluted wit...

example 3

A Two-Step Process having Gelatine and Alginate in the Second Shell

[0075]Step A: Same as Step A in Example 2.

[0076]Step B: A gelatine solution was prepared by dissolving 23.0 grams of gelatine 275 Bloom type A (isoelectric point of about 9) in 371 grams of deionized water under' agitation at 50° C. until completely dissolved. A sodium alginate (ISP Alginates) solution was prepared by dissolving 3.00 grams of sodium alginate in 503.8 grams of deionized water. The gelatine and sodium alginate solutions were combined to form a mixture. The pH of the mixture was adjusted to 5.00 with 10% aqueous phosphoric acid.

[0077]Step C: The mixture from Step B was added to the mixture with lumps formed in step A. Cooling was carried out under agitation to cause gelatine and alginate to form coacervates and coat the lumps formed in Step A to form an outer shell. The microcapsules thus formed had an average size of around 80 μm. Once the temperature had been cooled to 5° C., 2.1 grams of 50% gluteral...

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Abstract

Single-core and multi-core microcapsules are provided, having multiple shells, at least one of which is formed of a complex coacervate of two components of shell materials. The complex coacervate may be the same or different for each shell. Also provided are methods for making the microcapsules.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Patent Application No. 60 / 423,363 filed Nov. 4, 2002, which is incorporated by reference herein in its entirety.FIELD OF THE INVENTION[0002]This invention relates to microcapsules having multiple shells, to methods of preparing microcapsules and to their use.BACKGROUND OF THE INVENTION[0003]Microcapsules are small particles of solids, or droplets of liquids, inside a thin coating of a shell material such as starch, gelatine, lipids, polysaccharides, wax or polyacrylic acids. They are used, for example, to prepare liquids as free-flowing powders or compressed solids, to separate reactive materials, to reduce toxicity, to protect against oxidation and / or to control the rate of release of a substance such as an enzyme, flavour, a nutrient, a drug, etc.[0004]Ideally, a microcapsule would have good mechanical strength (e.g. resistance to rupture) and the microcapsule shell would provide a...

Claims

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Application Information

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Patent Type & AuthorityApplications(United States)
IPC IPC(8): A61K9/50A61P43/00A23L1/00A23L1/30A23L27/00B01J13/10B01J13/22
CPCA23L1/0029Y10T428/2982A23L1/3008A23V2002/00A61K9/5015A61K9/5057A61K9/5073A61K9/5084A61K9/5089B01J13/10B01J13/22A23L1/22016Y10T428/2989Y10T428/2984Y10T428/2985A23V2200/224A23V2250/5432A23V2250/187A23V2250/1868A23L33/12A23L27/72A23P10/30A61P43/00A61K9/50A61K9/16A61K47/42
InventorYAN, NIANXIJIN, YULAI
OwnerDSM NUTRITIONAL PROD