Microcapsules having multiple shells and method for the preparation thereof

US20050067726A1Inactive Publication Date: 2005-03-31DSM NUTRITIONAL PROD
77 Cites 146 Cited by

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Microcapsules having multiple shells and method for the preparation thereof
  • Microcapsules having multiple shells and method for the preparation thereof
  • Microcapsules having multiple shells and method for the preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

Multicore Microcapsules Prepared by One-Step Process for Comparison (Both First and Second Shells Having the Same Composition of Gelatine and Polyphosphate)

54.5 grams gelatine 275 Bloom type A (isoelectric point of about 9) was mixed with 600 grams of deionized water containing 0.5% sodium ascorbate under agitation at 50° C. until completely dissolved. 5.45 grams of sodium polyphosphate was dissolved in 104 grams of deionized water containing 0.5% sodium ascorbate. 90 grams of a fish oil concentrate containing 30% eicosapentaenoic acid ethyl ester (EPA) and 20% docosahexaenoic acid ethyl ester (DHA) (available from Ocean Nutrition Canada Ltd.) was dispersed with 1.0% of an antioxidant (mixed natural tocopherols) into the gelatine solution with a high speed Polytron™ homogenizer at 5,500 rpm for 6 minutes. An oil-in-water emulsion was formed. The oil droplet size had a narrow distribution with an average size of about 1 μm measured by Coulter™ LS230 Particle Size Analyzer. The emul...

example 2

A Two-Step Process With Gelatine and Polyphosphate in Both First and Second Shells, but Having Different Compositions

Step A: 15.6 grams gelatine 275 Bloom type A (isoelectric point of about 9) was mixed with 172 grams of deionized water containing 0.5% sodium ascorbate under agitation at 50° C. until completely dissolved. 1.56 grams of sodium polyphosphate was dissolved in 29.7 grams of deionized water containing 0.5% sodium ascorbate. 69 grams of a fish oil concentrate containing 30% eicosapentaenoic acid ethyl ester (EPA) and 20% docosahexaenoic acid ethyl ester (DHA) (available from Ocean Nutrition Canada Ltd.) was dispersed with 1.0% of an antioxidant (mixed natural tocopherols) into the gelatine solution with a high speed Polytron™ homogenizer at 6,100 rpm for 4 minutes. An oil-in-water emulsion was formed. The oil droplet size had a narrow distribution with an average size of about 1 μm measured by Coulter™ LS230 Particle Size Analyzer. The emulsion was diluted with 319 gram...

example 3

A Two-Step Process Having Gelatine and Alginate in the Second Shell

Step A: Same as Step A in Example 2.

Step B: A gelatine solution was prepared by dissolving 23.0 grams of gelatine 275 Bloom type A (isoelectric point of about 9) in 371 grams of deionized water under agitation at 50° C. until completely dissolved. A sodium alginate (ISP Alginates) solution was prepared by dissolving 3.00 grams of sodium alginate in 503.8 grams of deionized water. The gelatine and sodium alginate solutions were combined to form a mixture. The pH of the mixture was adjusted to 5.00 with 10% aqueous phosphoric acid.

Step C: The mixture from Step B was added to the mixture with lumps formed in step A. Cooling was carried out under agitation to cause gelatine and alginate to form coacervates and coat the lumps formed in Step A to form an outer shell. The microcapsules thus formed had an average size of around 80 μm. Once the temperature had been cooled to 5° C., 2.1 grams of 50% gluteraldehyde was ad...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Fractionaaaaaaaaaa
Diameteraaaaaaaaaa
Diameteraaaaaaaaaa
Login to View More

Abstract

Single-core and multi-core microcapsules are provided, having multiple shells, at least one of which is formed of a complex a coacervate of two components of shell materials. The complex coacervate may be the same or different for each shell. Also provided are methods for making the microcapsules.

Description

FIELD OF THE INVENTION This invention relates to microcapsules having multiple shells, to methods of preparing microcapsules and to their use. BACKGROUND OF THE INVENTION Microcapsules are small particles of solids, or droplets of liquids, inside a thin coating of a shell material such as starch, gelatine, lipids, polysaccharides, wax or polyacrylic acids. They are used, for example, to prepare liquids as free-flowing powders or compressed solids, to separate reactive materials, to reduce toxicity, to protect against oxidation and / or to control the rate of release of a substance such as an enzyme, flavour, a nutrient, a drug, etc. Ideally, a microcapsule would have good mechanical strength (e.g. resistance to rupture) and the microcapsule shell would provide a good barrier to oxidation, etc. A typical approach to meeting these requirements is to increase the thickness of the microcapsule wall. But this results in an undesirable reduction in the loading capacity of the microcapsu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
31 Mar 2005
Publication
US20050067726A1
IPC
A23L1/00; A23L1/30; A23L27/00; A61K9/50; B01J13/10; B01J13/22
CPC
A23L1/0029; Y10T428/2982; A23L1/3008; A23V2002/00; A61K9/5015; A61K9/5057; A61K9/5073; A61K9/5084
Inventors
YAN, NIANXI; JIN, YULAI