Tobacco and tobacco packaging material for preventing or reducing tobacco-associated injury in the aerodigestive tract of a subject

a technology of tobacco packaging material and tobacco-associated injury, which is applied in the field of preventing or reducing the pathogenesis of oxidant stressassociated diseases of the aerodigestive tract, can solve the problems of affecting the entire body of the tobacco consumer, oxidant burden of any tobacco consumption, and tobacco is a worldwide public health hazard, so as to prevent or reduce the risk of tobacco smoke-associated injury

Inactive Publication Date: 2010-05-06
TECHNION RES & DEV FOUND LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides ways to stop or minimize harm caused by smoking on the lungs and digestive system.

Problems solved by technology

The technical problem addressed in this patent text is how to protect against harmful effects caused by tobacco smoking through the use of oral compositions that contain specific proteins like L-glutathione and selenium sources. Previous methods involving systematic review and biochanical action have failed to adequately address these issues.

Method used

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  • Tobacco and tobacco packaging material for preventing or reducing tobacco-associated injury in the aerodigestive tract of a subject
  • Tobacco and tobacco packaging material for preventing or reducing tobacco-associated injury in the aerodigestive tract of a subject
  • Tobacco and tobacco packaging material for preventing or reducing tobacco-associated injury in the aerodigestive tract of a subject

Examples

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example 1

Hydroxocobalamin Provides Protection from Tobacco Smoke-Induced Loss of Aerodigestive Tract Antioxidant Defenses

[0121]Many common and highly debilitating oral diseases, such as cancer, periodontitis and gingivitis, result from, or are aggravated by consumption of tobacco products, such as tobacco smoking. For example, oral cancer, a frequently lethal and highly debilitating disease, results from tobacco consumption in 50-90% of cases world-wide. One widely accepted mechanism whereby cancer progression is promoted is via oxidant injury, such as protein damage caused by exposure to free radicals.

[0122]The present inventors have therefore analyzed the effects of TS on aerodigestive tract antioxidant defenses and have invented means to prevent such effects, as described below.

[0123]Exposure to Tobacco Smoke Leads to a Decrease in Oral Peroxidase and to an Increase in Protein Damage:

[0124]Oral peroxidase is the critical salivary enzymatic defense against upper digestive tract oxidant inj...

example 2

The Antioxidants Deferoxamine and Glutathione Prevent Upper Aerodigestive Tract Lymphocyte Death Associated with Exposure to Tobacco Smoke

[0160]Many diseases of the aerodigestive tract are associated with consumption of tobacco products or betel nut chewing. For example, oral SCC is the most common malignancy of the head and neck, having a high rate of morbidity and mortality. In as many as 90% of the cases, this cancer is induced by exposure of oral epithelial tells to tobacco products such as TS, or chewed betel nut. This exposure always occurs in the presence of saliva and presumably is induced by free radicals. Thus, the effects of TS on cells in the presence of saliva was examined, as described below.

[0161]Materials and Methods:

[0162]Mutagenic alterations of oral mucosal cells induced by TS occur in the presence of saliva (22, 23). Thus, in order to explore the interaction between TS and saliva on cells, intact cells were exposed to TS, alone or in the presence of saliva. Lymph...

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Abstract

Articles of manufacturing for preventing or reducing tobacco smoke- and smokeless-tobacco associated injury in the aerodigestive tract of a subject are disclosed, which comprise at least one agent capable of reducing or preventing tobacco associated loss of peroxidase activity in said aerodigestive tract, said at least one agent being selected from the group consisting of a cyanide chelator and an iron chelator.

Description

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Claims

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Application Information

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Owner TECHNION RES & DEV FOUND LTD
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