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Apparatus and method for electromagnetic treatment of plant, animal, and human tissue, organs, cells, and molecules

a technology of electromagnetic treatment and apparatus, applied in the field of apparatus and a method of in vitro and in vivo therapeutic and prophylactic treatment of plant, animal, and human tissue, organs, cells and molecules, can solve the problems of unnecessarily long treatment time, unfavorable use, unfavorable use, etc., and achieves the effect of short pulse duration and low peak amplitud

Inactive Publication Date: 2010-08-19
RIO GRANDE NEUROSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0012]An apparatus and a method for delivering electromagnetic signals to human, animal and plant target pathway structures such as molecules, cells, tissue and organs for therapeutic and prophylactic purposes. A preferred embodiment according to the present invention utilizes a Power Signal to Noise Ratio (“Power SNR”) approach to configure bioeffective waveforms and incorporates miniaturized circuitry and lightweight flexible coils. This advantageously allows a device that utilizes a Power SNR approach, miniaturized circuitry, and lightweight flexible coils, to be completely portable and if desired to be constructed as disposable and if further desired to be constructed as implantable.
[0017]It is another object of the present invention to employ significantly lower peak amplitudes and shorter pulse duration. This can be accomplished by matching via Power SNR, a frequency range in a signal to frequency response and sensitivity of a target pathway structure such as a molecule, cell, tissue, and organ, of plants, animals and humans.

Problems solved by technology

However, prior art in this field applies unnecessarily high amplitude and power to a target pathway structure, requires unnecessarily long treatment time, and is not portable.

Method used

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  • Apparatus and method for electromagnetic treatment of plant, animal, and human tissue, organs, cells, and molecules

Examples

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example 1

[0045]The Power SNR approach for PMF signal configuration has been tested experimentally on calcium dependent myosin phosphorylation in a standard enzyme assay. The cell-free reaction mixture was chosen for phosphorylation rate to be linear in time for several minutes, and for sub-saturation Ca2− concentration. This opens the biological window for Ca2+ / CaM to be EMF-sensitive. This system is not responsive to PMF at levels utilized in this study if Ca2+ is at saturation levels with respect to CaM, and reaction is not slowed to a minute time range. Experiments were performed using myosin light chain (“MLC”) and myosin light chain kinase (“MLCK”) isolated from turkey gizzard. A reaction mixture consisted of a basic solution containing 40 mM Hepes buffer, pH 7.0; 0.5 mM magnesium acetate; 1 mg / ml bovine serum albumin, 0.1% (w / v) Tween 80; and 1 mM EGTAl2. Free Ca2+ was varied in the 1-7 μM range. Once Ca2+ buffering was established, freshly prepared 70 nM CaM, 160 nM MLC and 2 nM MLCK ...

example 2

[0049]According to an embodiment of the present invention use of a Power SNR model was further verified in an in vivo wound repair model. A rat wound model has been well characterized both biomechanically and biochemically, and was used in this study. Healthy, young adult male Sprague Dawley rats weighing more than 300 grams were utilized.

[0050]The animals were anesthetized with an intraperitoneal dose of Ketamine 75 mg / kg and Medetomidine 0.5 mg / kg. After adequate anesthesia had been achieved, the dorsum was shaved, prepped with a dilute betadine / alcohol solution, and draped using sterile technique. Using a #10 scalpel, an 8-cm linear incision was performed through the skin down to the fascia on the dorsum of each rat. The wound edges were bluntly dissected to break any remaining dermal fibers, leaving an open wound approximately 4 cm in diameter. Hemostasis was obtained with applied pressure to avoid any damage to the skin edges. The skin edges were then closed with a 4-0 Ethilon ...

example 3

[0055]In this example Jurkat cells react to PMF stimulation of a T-cell receptor with cell cycle arrest and thus behave like normal T-lymphocytes stimulated by antigens at the T-cell receptor such as anti-CD3. For example in bone healing, results have shown both 60 Hz and PEMF fields decrease DNA synthesis of Jurkat cells, as is expected since PMF interacts with the T-cell receptor in the absence of a costimulatory signal. This is consistent with an anti-inflammatory response, as has been observed in clinical applications of PMF stimuli. The PEMF signal is more effective. A dosimetry analysis performed according to an embodiment of the present invention demonstrates why both signals are effective and why PEMF signals have a greater effect than 60 Hz signals on Jurkat cells in the most EMF-sensitive growth stage.

[0056]Comparison of dosimetry from the two signals employed involves evaluation of the ratio of the Power spectrum of the thermal noise voltage that is Power SNR, to that of ...

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Abstract

An apparatus and method for electromagnetic treatment of plants, animals, and humans comprising: configuring at least one waveform according to a mathematical model having at least one waveform parameter, said at least one waveform to be coupled to a target pathway structure; choosing a value of said at least one waveform parameter so that said at least waveform is configured to be detectable in said target pathway structure above background activity in said target pathway structure; generating an electromagnetic signal from said configured at least one waveform; and coupling said electromagnetic signal to said target pathway structure using a coupling device.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 11 / 003,108, filed Dec. 3, 2004 entitled “APPARATUS AND METHOD FOR ELECTROMAGNETIC TREATMENT OF PLANT, ANIMAL, AND HUMAN TISSUE, ORGANS, CELLS, AND MOLECULES which claims the benefit under 35 U.S.C. §119 of U.S. Provisional Patent Application No. 60 / 527,327, filed Dec. 5, 2003, titled “APPARATUS AND METHOD FOR ELECTROMAGNETIC TREATMENT OF PLANT, ANIMAL, AND HUMAN TISSUE, ORGANS, CELLS AND MOLECULES”.INCORPORATION BY REFERENCE[0002]All publications and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference.BACKGROUND OF THE INVENTION[0003]1. Field of the Invention[0004]This invention pertains generally to an apparatus and a method for in vitro and in vivo therapeutic and prophylactic treat...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N2/04A01G1/00A61N1/40A61N2/00A61N2/02
CPCA61N1/40A61N2/008A61N2/00A01G1/001A61N2/02
Inventor PILLA, ARTHUR A.
Owner RIO GRANDE NEUROSCI
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