Compositions and methods for modulating immune responses

a technology of immune response and composition, applied in the field of compositions and methods for modulating immune responses, can solve the problems of insufficient magnitude of immune response to many different antigens, which are often detectable, and cannot afford to protect against disease processes mediated by agents
US20100316646A1Inactive Publication Date: 2010-12-16ZYMOGENETICS INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ZYMOGENETICS INC
Publication Date
2010-12-16
Estimated Expiration
Not applicable · inactive patent
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Abstract

The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.
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Description

REFERENCE TO RELATED INVENTIONS

[0001] This application is a divisional of U.S. application Ser. No. 12 / 270,775, filed Nov. 13, 2008, which is a divisional of U.S. application Ser. No. 11 / 433,276, filed May 12, 2006, now abandoned, which claims the benefit of U.S. Provisional Application Ser. No. 60 / 680,374, filed May 12, 2005, U.S. Provisional Application Ser. No. 60 / 791,626, filed Apr. 13, 2006, and U.S. Provisional Application Ser. No. 60 / 795,005, filed Apr. 26, 2006 all of which are incorporated in their entirety herein by reference.BACKGROUND OF THE INVENTION

[0002] Positive and negative costimulatory signals play critical roles in the modulation of T cell activity, and the molecules that mediate these signals have proven to be effective targets for immunomodulatory agents. Positive costimulation, in addition to T cell receptor (TCR) engagement, is required for optimal activation of naive T cells, whereas negative costimulation is believed to be required for the acquisition of immu...

Claims

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