Gene relating to estimation of postoperative prognosis for breast cancer
a breast cancer and prognosis technology, applied in the field of genes relating to the estimation of the prognosis of breast cancer, can solve the problems of not being recognized as effective prognosis predicting means, no dominant reasons for determining the grade of malignancy and survival prognosis,
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example 1
[0204]Evaluation of gene expression function for prediction of the postoperative prognosis in estrogen receptor-negative breast cancer
(Tissue Sample)
[0205]An informed consent was obtained according to a guide line accepted by an ethics committee of Cancer Society and by Nippon Medical School, then, primary breast cancer and tissue from adjacent normal mammary gland were collected from breast cancer patients who undergone an operation in 1995 to 1997 in Cancer Society attached hospital (Tokyo). The tissue was quickly frozen and preserved at −80° C. For 954 patients, all members were clinically traced during a period of 5 years or more or until death, and samples were selected from 10 estrogen receptor-negative breast cancer patients died within 5 years after the operation (5y-D) and 10 patients survived free of disease for 5 years or more after the operation (5y-S). The backgrounds of both the patient groups were allowed to coincide in age, lymph node metastasis, tumor diameter and t...
example 2
[0233]Evaluation of gene expression function for prediction of the postoperative prognosis in node-negative breast cancer
(Tissue Sample)
[0234]A tissue sample was collected in the same manner as described in Example 1. Gene expression was investigated for tumors from 12 patients of node-negative (n0) cancer showed recurrence within 5 years after an operation (5Y-R) and 12 patients survived free of disease for 5 years or more after the operation (5Y-F). The clinical backgrounds of both the patient groups were allowed to coincide in age, lymph node metastasis, tumor diameter, condition of hormone receptor, and pathological tissue (Table 3). The follow up intermediate period was 7.8 years, and the average period between the initial operation and recurring was 2.7 years in the 5Y-R group. All patients underwent the adjuvant therapy described in Example 1.
(Clinical Pathological Data)
[0235]
TABLE 3ClimactericHistologicalDiameterTNM classification bCaseAgeconditionclassification aPosition(mm...
example 3
[0267]Evaluation of gene expression function for prediction of the postoperative prognosis in primary breast cancer
(Tissue Sample)
[0268]A tissue sample was collected in the same manner as described in Example 1. Among 954 patients clinically traced during a period of 5 years or more or until death after an operation for breast cancer in a period from 1995 to 1997, 10 cases of death within 5 years after an operation and 10 cases of survival free of disease for 5 years or more after an operation were selected as a sample. The clinical backgrounds between two patient groups were allowed to coincide as strictly as possible regarding age, metastasis to lymph node, tumor diameter and tissue type (Table 8). The clinical backgrounds of additional 20 cases used for testing the final prediction system are summarized in Table 9.
(Clinical Profile of Patients Used for Microarray Analysis)
[0269]
TABLE 8CaseTNMStageAgeNLalybfcERdSurvivedMS1210II52412PMS2220II47201PMS3220II40501NMS4220II64301N / ADead...
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