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Small enzyme-containing granules

a technology of enzymes and granules, which is applied in the field of small enzyme-containing granules, can solve the problems of ineffective coating of agglomerates, inability to bind together, and strong tendency of fluidized granules to agglomerate or stick together

Inactive Publication Date: 2013-10-31
DANISCO US INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides a population of enzyme-containing granules with a single core consisting of one or more inorganic salts. The granules contain an enzyme-containing layer coated over the core and optionally a barrier salt layer containing sodium sulfate or a mixture of salts. The granules also contain an outer coating layer containing a polymer and optionally a pigment. The granules can be used in detergent compositions, textile processing compositions, and animal feed compositions. The method of making the granules involves coating an enzyme-containing layer onto cores in a fluidized bed spray coater. The granules produced have a single core with a diameter of 150 to 300 microns and a bulk density greater than 1.2 g / ml. The granules can be pre-sieved to a particle dispersity index of about 2.0 or less. The barrier salt layer can contain sodium sulfate or a mixture of salts, and the outer coating layer can contain a polymer and a pigment.

Problems solved by technology

However, with smaller granules, there is a strong tendency for the fluidized granules to agglomerate or stick together when sprayed with enzymes and other solutions, due to the presence of binders in the coating solutions.
Agglomeration of fine powders is often employed deliberately to produce dry products, but such agglomerated powders are often undesirable because they typically have a broad particle size distribution, do not flow freely, and tend to form dusts or break down to fines when subjected to shear, impact, or other forces encountered in handling.
Furthermore, coating of agglomerates is typically inefficient, since much of the coating material is incorporated into interstitial zones, rather than evenly coating the substrate particles.

Method used

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  • Small enzyme-containing granules

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0088]grams of sodium sulfate crystals, with a particle diameter size range of 150 μm to 250 μm, was loaded into a Vector FL-1 fluid bed coater and fluidized. To this, 5557 grams of a solution containing 23,608 U / ml of active neutral cellulase, 3.6% Sorez-100 from ISP Corp. (an anti-redeposition agent), and 0.36% polyvinyl alcohol (5 / 88 from Erkol) was spray-coated onto the sodium sulfate crystals.

[0089]The spray coating parameters were as follows:

Solution Spray Rate6.5 gpm (grams per minute), increasing to15.4 gpm over 2.5 hours.Kept at 15.4 gpm for remainder of experiment.Inlet Temperature85° C., increased to 90° C. after 1 hourOutlet temperatureBetween 42° C. and 46° C.Fluidization Air Flow50 cfm (cubic feet per minute)Atomization Air Pressure40 pounds per square inch (psi), increasing to50 psi over 2.5 hours.

[0090]3017 grams of product was harvested, of which 2899 grams passed through a 40 mesh sieve (425 μm). The particle size distribution is shown in Table 1 and in FIG. 1.

TABL...

example 2

[0091]1395 grams of the enzyme granules produced in Example 1 were loaded into a Vector FL-1 fluid bed coater and fluidized. 861 grams of an aqueous solution containing 172 grams of sodium sulfate were then spray coated onto the enzyme granules.

[0092]The spray coating parameters were as follows:

Solution Spray Rate14.9 gpmInlet Temperature90° C.Outlet temperatureBetween 42° C. and 46° C.Fluidization Air Flow53 cfmAtomization Air Pressure40 psi

[0093]1483 grams of final product was harvested. The particle size distribution is shown in Table 2 and in FIG. 1.

TABLE 2Particle Size Analysis for Enzyme GranulesProduced in Example 2Amount ofParticle size (μm)particles (%)Over 4253.8354-4250.0297-3540.3210-29767.1149-21028.7Under 1490.1

example 3

[0094]1395 grams of the enzyme granules produced in Example 2 were loaded into a Vector FL-1 fluid bed coater and fluidized. 861 grams of an aqueous solution containing 52 grams of PVA (Erkol 5 / 88), 112 grams of talc (Nytal 400), and 8.6 grams of Neodol 23 / 6.5 were then spray coated onto the enzyme granules.

[0095]The spray coating parameters were as follows:

Solution Spray Rate10.8 gpmInlet Temperature95° C.Outlet temperatureBetween 49° C. and 50° C.Fluidization Air Flow50 cfmAtomization Air Pressure46 psi

[0096]1477 grams of final product was harvested. The particle size distribution is shown in Table 3 and in FIG. 1.

TABLE 3Particle Size Analysis for Enzyme GranulesProduced in Example 3Amount ofParticle size (μm)particles (%)Over 4259.2354-4258.6297-3547.4210-29764.5149-21010.4Under 1490.0

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Abstract

The invention provides small enzyme-containing granules having an inorganic salt core and an enzyme-containing layer coated over the core, and methods for producing such granules. The majority of the enzyme granules are less than 300 μm in diameter. The granules are suitable for incorporation into compositions such as cleaning, textile processing, and animal feed compositions.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 12 / 867,172, filed Nov. 22, 2010, which is the National Stage of International Application No. PCT / US2009 / 033766, filed Feb. 11, 2009, which claims the benefit of U.S. Provisional Application No. 61 / 028,748, filed Feb. 14, 2008, and U.S. Provisional Application No. 61 / 115,146, filed Nov. 17, 2008, both of which are incorporated by reference herein in their entireties.FIELD OF THE INVENTION[0002]The invention relates to small enzyme-containing granules produced in a fluidized bed spray coater, wherein the majority of the particles have a diameter of less than 300 microns and contain a single core.BACKGROUND[0003]Enzyme-containing granules are incorporated into products in several industries, including detergent, textile-processing, food (e.g., baking), animal feed, and fuel ethanol industries. Such granules may be prepared by a number of technologies, including fluidized...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12N9/98
CPCC12N9/98C12N9/2437C12N11/14C12Y302/01004A23K20/189C11D3/38645C11D17/0039
Inventor BECKER, NATHANIEL T.CHRISTENSEN, ROBERT I.GEBERT, MARK S.VAHA-VAHE, ANTTI PEKKA
Owner DANISCO US INC