Laser Induced Collagen Crosslinking in Tissue

US20180193188A1Inactive Publication Date: 2018-07-12THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
Publication Date
2018-07-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage or cornea, without using a photosensitizer (e.g., riboflavin), by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of tissue. In an embodiment, the femtosecond laser operates in the infrared frequency range.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of International Application No. PCT / US2016 / 058353 filed Oct. 23, 2016, which claims priority to U.S. Provisional Application No. 62 / 245,805 filed Oct. 23, 2015, U.S. Provisional Application No. 62 / 358,035 filed Jul. 3, 2016, and U.S. Provisional Application No. 62 / 380,713 filed on Aug. 29, 2016. The entire contents of each of the above applications is hereby expressly incorporated by reference.BACKGROUND

[0002] Collagen is an abundant protein in animals. The mechanical properties and structural stability of collagen based tissues, such as cartilage, tendons, ligaments, or corneal stroma, can be influenced by increasing collagen cross-links (CXL), in the form of intra or inter molecule chemical bonds. CXL are naturally formed in tissues, but inducing new or additional CXL can be beneficial. Strength and the ability to bend under tension are two characteristics of collagen, which is the significant componen...

Claims

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