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Treatment of alphavirus-induced inflammation

Inactive Publication Date: 2019-08-22
GRIFFITH UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent is about a method for treating people who have been infected with alphavirus. The method involves giving them a certain drug called pentosan polysulfate or a salt of it to reduce inflammation and prevent damage to cartilage in the body. The invention also includes using this drug in making a medicine to treat alphavirus infections.

Problems solved by technology

However, there have been no studies to elucidate the impact of alphaviruses on cartilage and the proteoglycan matrix of the joint.

Method used

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  • Treatment of alphavirus-induced inflammation
  • Treatment of alphavirus-induced inflammation
  • Treatment of alphavirus-induced inflammation

Examples

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Embodiment Construction

[0026]The inflammation arising out of the alphavirus infection is in the joints and / or muscles. Alternatively, the inflammation may be confined to the joints or it may be confined to the muscles. In some embodiments, the inflammation will be in both the joints and the muscles.

[0027]Although the present invention is directed towards alphavirus infections generally, in some embodiments, the alphavirus infection will be selected from the group consisting of Ross River virus, chikungunya virus and Barmah Forest virus.

[0028]In particular, the present invention in one embodiment is directed towards Ross River virus.

[0029]In particular, the present invention in another embodiment is directed towards chikungunya virus.

[0030]In particular, the present invention in another embodiment is directed towards Barmah Forest virus.

[0031]Administration of the effective amount of pentosan polysulfate to a subject infected with an alphavirus is parenteral.

[0032]In some embodiments when a joint is suffer...

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Abstract

Disclosed is a method of treating alphavirus infections, particularly in humans, in which pentosan polysulfate is administered to an infected subject. Whilst not effecting the viral load in a subject, the pentosan polysulfate acts to reduce inflammation in tissues, such as the muscles, and in the joints of a subject. In addition, cartilage damage in the joints may be reduced. The reduction in inflammation and / or cartilage damage acts to reduce the severe pain experienced by subjects suffering from alphavirus infections, such as Ross River virus, chikungunya virus and Barmah Forest virus.

Description

TECHNICAL FIELD[0001]This invention relates to the treatment of animals, especially humans, infected with alphaviruses and more particularly to a treatment directed to the reduction of inflammation and / or cartilage damage arising from the infection.BACKGROUND[0002]Arthropod-borne arthritogenic alphaviruses such as Ross River virus (RRV) and chikungunya virus (CHIKV) cause large epidemics of severe musculoskeletal disease. They have been progressively expanding their global distribution, regularly emerging in new regions of the world (1, 2). The hallmark of alphavirus disease is crippling joint pain and arthritis, which often has an extended duration leaving patients bed-ridden and incapacitated. In 2014-2015, CHIKV further expanded its global distribution by entering the Americas and is circulating in several Caribbean islands. As of 23rd May 2016, the Pan American Health Organization (PAHO) reported an estimated total of over 1 5 million cases since 2014, with 100,000 reported in 2...

Claims

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Application Information

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IPC IPC(8): A61K31/737A61K9/00A61P31/14A61P19/02A61P29/00
CPCA61K31/737A61K9/0019A61P31/14A61P19/02A61P29/00Y02A50/30
Inventor MAHALINGAM, SURENDRANHERRERO, LARA JOSEFINA
Owner GRIFFITH UNIVERSITY