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Antifibrinolytic compounds

a technology of antifibrinolytic compounds and sulfonium salts, which is applied in the field of antifibrinolytic compounds, can solve the problems that no one has proposed the application of sulfonium salt containing compounds in developing antifibrinolytics, and achieve the effects of limiting bleeding, reducing the contribution of apolipoproteins, and limiting tissue growth

Inactive Publication Date: 2020-02-06
CHIBBER BAKSHY A
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

The present patent application claims new chemical structures that mimic the amino acid Lysine, which is involved in the clotting process of blood. These structures contain sulfonium groups, which offer a better chance of disrupting the function of Lysine in the body. The use of sulfonium groups has been previously limited to mono- and di-positive amine functions. The new compounds have been designed to target specific protein structures and can be used as anti-fibrinolytic agents. The technical effect of this patent is the development of new compounds that can better disrupt the function of Lysine in the body and potentially prevent blood clots.

Problems solved by technology

However, until now, no one has proposed the application of sulfonium salt containing compounds in developing antifibrinolytics.

Method used

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Embodiment Construction

[0123]All terms as used herein in this application, unless otherwise stated, shall be understood in their ordinary meaning as known in the art. Other more specific definitions for certain terms as used in the present application are as set forth below and are intended to apply uniformly throughout the specification and claims unless an otherwise expressly set out definition provides a broader definition.

[0124]The terms “halogen” and “halo”, alone or in combination with other groups, refer to fluorine, chlorine, bromine and iodine. Preferred halogens include chlorine and fluorine.

[0125]The term “C1-4alkyl” and “(C1-C4)alkyl”, alone or in combination with other groups, means a branched or straight chain monovalent alkyl containing 1-4 Carbon atoms. Examples include methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, and tert-butyl.

[0126]The terms “HaloC1-4alkyl” and “halo(C1-C4)alkyl” refer to a C1-4alkyl group as defined herein, wherein one or more hydrogens have been independent...

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Abstract

The present invention provides novel antifibrinilytic compounds, processes for their preparation, pharmaceutical and veterinary compositions thereof, and their use in medicine, in particular for the treatment of bleeding.

Description

RELATED APPLICATIONS[0001]This application claims priority to Ser. No. 15 / 524,250, filed on May 3, 2017, which is the national phase application of PCT / US2015 / 058852 under 35 U.S.C. § 371 filed Nov. 3, 2015, which claims the benefit of U.S. Provisional Patent Application No. 62 / 200,047 filed on Aug. 2, 2015 and U.S. Provisional Patent Application No. 62 / 074,141 filed on Nov. 3, 2014; the entirety of each of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to novel antifibrinolytic compounds, processes for their preparation, pharmaceutical compositions thereof, and their use in medicine, particularly for the treatment of bleeding.BACKGROUND OF THE INVENTION[0003]A major goal in surgery, as well as treatment of major tissue damage, is to avoid or minimize bleeding to ensure the formation of stable and secure haemostatic plugs that are not easily dissolved by fibrinolytic enzymes. It is of importance to ensure quick and effective forma...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07C229/28C07D487/04C07D207/404C07C381/12C07K5/083C07K5/103C07K5/12C07C281/12
CPCC07K5/12C07C2601/14C07C281/12C07D487/04C07K5/0806C07D207/404C07C381/12C07C229/28C07B2200/07C07K5/1008A61K38/36C07C237/12C07C271/22C07C323/52C07C323/55C07C323/60
Inventor CHIBBER, BAKSHY A.
Owner CHIBBER BAKSHY A
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