Fusion proteins comprising a fragment of Vibrio cholerae exotoxin A
a technology of exotoxin and fusion proteins, which is applied in the field of therapies based on vibrio cholerae exotoxin, can solve the problems of severe systemic toxicities, drug resistance, disease relapse, etc., and achieve the effect of prolonging the half-life of plasma and/or reducing immunogenicity
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[0089]Recombinant exotoxins from Vibrio cholerae are useful for the therapeutic treatment of a variety of human diseases, particularly diseases characterized by an abundance or excess of undesired cells. Vibrio exotoxins have superior biophysical properties, including robust folding and enhanced solubility when expressed at high levels in E. coli compared to similar toxins known in the art. Vibrio exotoxin fusion proteins comprising exogenous cell-targeting moieties bind to selected surface targets of cells of interest and induce intoxication. In addition, such fusion proteins in which the native activation sequence has been replaced with a modifiable activation moiety can be acted upon by a second proactivator or activator that can be made to be or is naturally specific to the cell that is to be targeted for intoxication. When Vibrio exotoxin activation sequences are replaced with those of exogenous proteases, the resulting engineered toxins are more easily activated by site-specif...
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