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Composition for therapy of diseases with ultrasonic and pharmaceutical liquid composition containing the same

a technology of ultrasonic and pharmaceutical liquid, applied in ultrasonic/sonic/infrasonic diagnostics, echographic/ultrasound-imaging preparations, peptide/protein ingredients, etc., can solve the problems of less effect of ultrasound at the desired portion, burns or unnecessary heat at the other portion than the desired portion, etc., to enhance the effect of ultrasound, and reduce the effect of energy

Inactive Publication Date: 2000-10-31
EKOS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present inventors have intensively studied on the enhancement of the effects of ultrasound with a lower energy of a ultrasonic vibration and have found that a booster comprising a plenty of microbubbles of a gas in a liquid is useful for the desired enhancement of the effects of ultrasound.

Problems solved by technology

However, too higher energy of a ultrasonic vibration causes disadvantageously burns or unnecessary heat at the portion other than the desired portion.
On the other hand, when the energy of a ultrasonic vibration is lowered for eliminating such disadvantages, there is a problem of less effect of the ultrasound at the desired portion.

Method used

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  • Composition for therapy of diseases with ultrasonic and pharmaceutical liquid composition containing the same
  • Composition for therapy of diseases with ultrasonic and pharmaceutical liquid composition containing the same
  • Composition for therapy of diseases with ultrasonic and pharmaceutical liquid composition containing the same

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of a Booster:

A 5% human serum albumin (8 ml) in a 10 ml-volume syringe is exposed to ultrasound with a sonicator (frequency, 20 KHz) by which vibration is given to the human serum albumin and a plenty of microbubbles of air are formed in the human serum albumin to give a booster comprising a human serum albumin containing a plenty of microbubbles of air.

example 2

Preparation of a Pharmaceutical Liquid Composition:

The 5% human serum albumin containing a plenty of microbubbles of air prepared in Example 1 is mixed with urokinase (concentration 1200 IU / ml) to give the desired pharmaceutical liquid composition.

Experiment

1. Forming Artificial Thrombosis

An artificial thrombosis was formed by Chandler's method. A blood (1 ml) collected from healthy human (two persons) was entered into a flexibale tube (inside diameter 3 mm, length 265 mm) and thereto was added calcium chloride, and then the tube was made a loop like shape, which was rotated at 12 r.p.m. for 20 minutes to give an artificial thrombosis model.

2. Ultrasonic Catheter

A ceramic ultrasonic element (width 2 mm, length 5 mm, thickness 1 mm) was inserted into the tip of a cetheter (diameter 2 mm), and an oscillating element was connected to an oscillator provided outside with a fine connector passed through the catheter. A fine tube for pouring a test solution was provided at an opening oppos...

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Abstract

A booster comprising a plenty of microbubbles of a gas in a liquid, e.g. about 4x107 cells / ml of microbubbles of a gas having a diameter of 0.1 to 100 mu m in a 3 to 5% human serum albumin solution, and a pharmaceutical liquid composition comprising the booster as set forth above and a medicament, which are useful for the therapy of various diseases together with exposure of ultrasonic, where the therapeutic effects of the medicament is enhanced by the application of ultrasound in the presence of the booster.

Description

This invention relates to a booster useful for enhancing the effects of ultrasound in the therapy of various diseases and a pharmaceutical liquid composition containing the booster and a medicament which shows enhanced diffusion and penetration of the medicament into the body by applying ultrasound. More particularly, it relates to a booster useful for therapy of various disease by applying ultrasound which comprises a plenty of microbubbles of a gas in a liquid, a pharmaceutical liquid composition comprising a plenty of microbubbles of a gas and a medicament in a liquid, and the use thereof in the therapy of various diseases while applying ultrasound.Prior ArtIt is known that various diseases are remedied by the aid of ultrasonic vibration. For example, it is described in Japanese Patent First Publication (Kokai) No. 115591 / 1977, etc. that percutaneous absorption of a medicament is enhanced by applying a ultrasonic vibration. Japanese Patent First Publication (Kokai) No. 180275 / 199...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/00A61K9/50A61K49/22
CPCA61K9/0009A61K9/5052A61K49/223A61K41/0028A61K41/0047A61K41/0004
Inventor TACHIBANA, KATSUROTACHIBANA, SHUNRO
Owner EKOS CORP
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