Long-acting cefquinome sulfate injection and preparation method thereof

A technology of cefquinoxime sulfate and injection, applied in the field of medicine, can solve problems such as short action time, and achieve the effects of slow release, cost saving, and long-term storage without discoloration

CN103751103AActive Publication Date: 2014-04-30AMICOGEN CHINA BIOPHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2014-04-30

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Abstract

The invention relates to a long-acting cefquinome sulfate injection. The injection is prepared by a method in the following steps: adding cefquinome sulfate into an ethanol solution containing ethyecellulose and hydroxy propyl cellulose; filtering, sterilizing and performing spray-drying to obtain a cefquinome sulfate carrier; adding a suspending agent, a dispersing agent and a stabilizing agent into partial injection solvent, dissolving at 100 DEG C, and adding an injection solvent to the whole amount, and performing dry heat sterilization at 150 DEG C for 1 hour; cooling the dispersion liquid to room temperature, adding the cefquinome sulfate carrier into the dispersion liquid, and uniformly stirring; passing through a high-speed cutting dispersion machine to prepare the long-acting cefquinome sulfate injection. The prepared suspension injection is uniform in granularity, good in fluidity, slow in settlement, good in redispersion property, wall adhesion prevention of liquid medicine, good needle cleaning performance, no discoloration after long-term storage and stable chemical property. After the preparation is injected in a pig in an intramuscular manner, the preparation is slowly released, long in elimination half life and smooth in plasma concentration, can be used for prolonging the effective action duration of the medicine in the body and reducing the number of administration times, and is convenient to use.
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Description

technical field

[0001] The invention belongs to the field of medicine and relates to a new dosage form of veterinary medicine, in particular to a long-acting cefquinome sulfate injection and a preparation method thereof. Background technique

[0002] Cefquinoxime is the fourth-generation cephalosporin antibiotic for animals. It is a broad-spectrum and highly effective cephalosporin antibiotic. Compared with the third-generation cephalosporin, it has a wider antibacterial spectrum and stronger bactericidal effect. Its intrinsic antibacterial activity is stronger than that of the first three generations of cephalosporins. Compared with the first three generations of cephalosporins, the fourth generation of cephalosporins requires less dosage, has strong sensitivity to treating bacteria, has a long plasma half-life, and has no nephrotoxicity. It has a strong killing effect on Staphylococcus aureus, Streptococcus, Pseudomonas aeruginosa, Enterobacteriaceae (Escherichia coli, Sal...

Examples

Embodiment 1

[0030] A long-acting cefquinome sulfate injection consists of the raw materials of the following components:

[0031] Each 100ml injection contains the following components:

[0032]

[0033] The balance is the solvent for injection

[0034] Described suspending agent is hydrogenated castor oil;

[0035] The dispersant is span-60;

[0036] The stabilizer is PG;

[0037] The injection vehicle is ethyl oleate for injection.

[0038] A preparation method for long-acting cefquinome sulfate injection, specifically comprising the following steps:

[0039] (1) Add 10g of ethyl cellulose and 1g of hydroxypropyl cellulose to 500ml of 70wt% ethanol aqueous solution, then add 6g of cefquinome sulfate (containing 5g of cefquinome) to the above solution, at room temperature , stirred and dissolved, filtered through a 0.22 μm microporous membrane to sterilize, and spray-dried to obtain the cefquinome sulfate slow-release carrier;

[0040] (2) Add 1g of hydrogenated castor oil, 0.2g...

Embodiment 2

[0043] A long-acting cefquinome sulfate injection consists of the raw materials of the following components:

[0044] Each 1000ml injection contains the following components:

[0045]

[0046] The balance is the solvent for injection

[0047] Described suspending agent is aluminum stearate;

[0048] The dispersant is span-60;

[0049] The stabilizer is vitamin E;

[0050] The injection vehicle is soybean oil for injection.

[0051] A preparation method for long-acting cefquinome sulfate injection, specifically comprising the following steps:

[0052] (1) Add 50g of ethyl cellulose and 5g of hydroxypropyl cellulose into 2500ml of 70wt% ethanol aqueous solution, then add 30g of cefquinome sulfate (containing 25g of cefquinome) into the above solution, and place at room temperature , stirred and dissolved, filtered through a 0.22 μm microporous membrane to sterilize, and spray-dried to obtain the cefquinome sulfate slow-release carrier;

[0053] (2) Add 5g of aluminum st...

Embodiment 3

[0056] A long-acting cefquinome sulfate injection consists of the raw materials of the following components:

[0057] Each 10000ml injection contains the following components:

[0058]

[0059] The balance is the solvent for injection

[0060] Described suspending agent is beeswax;

[0061] The dispersant is Tween-80;

[0062] The stabilizer is PG and BHT;

[0063] The injection vehicle is glycerol triacetate for injection.

[0064] A preparation method for long-acting cefquinome sulfate injection, specifically comprising the following steps:

[0065] (1) Add 750g of ethyl cellulose and 100g of hydroxypropyl cellulose to 10000ml of 70wt% ethanol aqueous solution, then add 120g of cefquinome sulfate (containing 100g of cefquinome) to the above solution, at room temperature , stirred and dissolved, filtered through a 0.22 μm microporous membrane to sterilize, and spray-dried to obtain the cefquinome sulfate slow-release carrier;

[0066] (2) Add 200g of beeswax, 10g of ...