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64 results about "Par 1 antagonist" patented technology

Protease-activated receptor-1 (PAR-1) antagonists are known to be potent antiplatelet agents that are also complementary to other antiplatelet therapies. Vorapaxar and atopaxar are currently the two PAR-1 antagonist antiplatelet agents that have undergone extensive clinical development.

"The Use of a PAR-1 Antagonist in Combination with a P2Y12 ADP Receptor Antagonist for Inhibition of Thrombosis"

The treatment and prevention of thrombotic events are provided through co-administration of PAR-1 and the P2Y12 ADP receptor antagonists. Combined inhibition of the PAR-1 and the P2Y12 ADP platelet activation pathways had synergistic antithrombotic and antiplatelet effects, as demonstrated in co-administration of SCH 602539 and cangrelor.
Owner:MERCK SHARP & DOHME CORP

Compound with aniline and diene fluoro adamantane structure and preparation method and application thereof

The invention relates to the field of drugs relevant to thrombotic diseases, in particular to a PAR-1 antagonist with an aniline and diene fluoro adamantane structure, a preparation method of the PAR-1 antagonist and the application of the PAR-1 antagonist. The structural general formula of the PAR-1 antagonist is specified in the specification, wherein R1 and R2 are selected from alkyl groups of H and C1-C5 respectively.
Owner:邳州市润宏实业有限公司

Exocyclic imine compound containing benzo five-membered heterocycle, preparation method and application of exocyclic imine compound

The invention relates to the field of medicines relevant to thrombotic diseases, in particular to a PAR (protease activated acceptor)-1 antagonist with an exocyclic imine structure containing benzo five-membered heterocycle, a preparation method of the PAR-1 antagonist, a medicine composition containing the PAR-1 antagonist and application of the PAR-1 antagonist to medicines for treating the thrombotic diseases. R1, R2 and R3 are independently selected from alkyl groups of C1, C2, C3, C4 and C5, and X is selected from O and C(CH3)2.
Owner:TIANJIN INSTITUTE OF PHARMA RESEARCH

Nitrile-grouping benzene diene tetrazole compound and preparation method and application thereof

The invention relates to the field of medicine correlated to thrombotic diseases, in particular to a PAR-1 antagonist with a nitrile-grouping benzene diene tetrazole structure and a preparation method and application of the antagonist. As shown in the description, R1 represents an alkyl group of H, C1-C3 and a naphthenic base of C3-C5.
Owner:HONGGUAN BIO PHARMA CO LTD

Halogenated phenyl-containing trans-cyclohexane amide compound and application thereof

The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a trans-cyclohexane amide structured PAR-1 antagonist containing structures, such as halogenated phenyl and the like, a preparation method of the antagonist and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C1-C3 alkyl, C3-C5 cycloalkyl and halogen substituent.
Owner:ZHEJIANG PHARMA COLLEGE

Halogenated pyridyl containing trans-cyclohexane amide compound and application thereof

The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a trans-cyclohexane amide structured PAR-1 antagonist containing structures, such as halogenated pyridyl and the like, a preparation method of the antagonist and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C1-C3 alkyl and F, Cl, Br and I substituent.
Owner:ZHEJIANG PHARMA COLLEGE

Compound containing alcoxyl phenyl group and diene adamantane structure and preparation method and application thereof

The invention relates to the field of medicine relevant to thrombotic diseases, in particular to a PAR-1 antagonist containing an alcoxyl phenyl group and a diene adamantane structure and a preparation method and application of the PAR-1 antagonist. According to the general formula (please see the specification), R is selected from an alkyl group of H, an alkyl group of C1-C5 and an alkyl group of C3-C8.
Owner:HONGGUAN BIO PHARMA CO LTD

One category of oxadiazole sulfoxide compounds comprising alcoxyl p-substituted benzene, and preparation method and application thereof

The invention relates to the field of drugs associated with thrombotic diseases, in particular to a category of PAR-1 antagonists of an oxadiazole sulfoxide structure comprising alkoxy p-substituted benzene, a preparation method of the PAR-1 antagonists, and application of drug combinations comprising the alkoxy p-substituted benzene and the alkoxy p-substituted benzene in preparation of the drugs for treating the thrombotic diseases. Please see the formula in the specification, wherein R1 and R2 are defined according to the description in the specification.
Owner:肇庆市科至自动化设备有限公司

Compound containing aniline and diene adamantane structure and preparation method and application thereof

The invention relates to the field of medicine relevant to thrombotic diseases, in particular to a PAR-1 antagonist containing an anilino group and a diene adamantane structure and a preparation method and application of the PAR-1 antagonist. According to the general formula (please see the specification), R<1> and R<2> are selected from an alkyl group of H and an alkyl group of C1-C5 respectively.
Owner:HONGGUAN BIO PHARMA CO LTD

Halogenated phenyldiene tetrazole compound, its preparation method and use

The invention relates to the field of medicine correlated to thrombotic diseases, in particular to a PAR-1 antagonist with a halobenzene diene tetrazole structure and a preparation method and application thereof. As shown in the description, R1 represents an alkyl group of H, C1-C3 and a naphthenic base of C3-C5, and R2 represents a halogen substituted base.
Owner:铜陵易难信息科技有限公司

Oxadiazole sulfoxide compound containing amino substituted benzene and preparation method and purposes thereof

The invention relates to the field of medicines related with thrombotic diseases, in particular to PAR-1 antagonists which contain the amino substituted benzene and are of an oxadiazole sulfoxide structure, a preparation method thereof, medicine combinations containing the PAR-1 antagonists and applications of the PAR-1 antagonists in preparing medicines for treating thrombotic diseases. The formula is as follows, wherein the definition of R is as described in the specification.
Owner:FOSHAN SAIWEISI MEDICINE SCI & TECH

Alkoxy phenyl substituted trans-cyclohexane amide compound and application thereof

The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a terminal alkoxy phenyl substituted trans-cyclohexane amide structured PAR-1 antagonist, a preparation method thereof and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C1-C3 alkyl and C3-C5 cycloalkyl.
Owner:ZHEJIANG PHARMA COLLEGE

Trans-cyclohexane amide compound and preparation method and medicinal application thereof

The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a trans-cyclohexane amide structure containing PAR-1 antagonist, a preparation method thereof and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C3-C8 cycloalkyl.
Owner:ZHEJIANG PHARMA COLLEGE

Compound containing nitrobenzene and diene adamantine structure and preparation method and application of compound

The invention relates to the field of medicine related to thrombotic diseases, in particular to a PAR-1 antagonist shown in the specification and containing a nitrobenzene and diene adamantine structure and a preparation method and application of the PAR-1 antagonist.
Owner:HONGGUAN BIO PHARMA CO LTD

2-pyridyl trans-cyclohexane amide compound and application thereof

The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a formula (I) (shown in specifications) structured 2-pyridyl trans-cyclohexane amide structure-containing PAR-1 antagonist and application of the antagonist in preparation of medicines for treating thrombotic diseases.
Owner:ZHEJIANG PHARMA COLLEGE

Oxadiazole sulfoxide compound with alcoxyl substituted benzene and preparation method and application thereof

The invention relates to the field of drugs relevant to thrombotic diseases, in particular to a PAR-1 antagonist of an oxadiazole sulfoxide structure with alkoxy p-substituted phenyl, a preparation method of the PAR-1 antagonist and the application of the PAR-1 antagonist of the oxadiazole sulfoxide structure with the alkoxy p-substituted phenyl in thrombotic disease treatment drug preparation. The structural general formula is specified in the specification, wherein R1 and R2 are defined in the specification.
Owner:珠海横琴长满欧国际贸易有限公司

Alkoxypyridyl-containing trans-cyclohexane amide compound and application thereof

The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a trans-cyclohexane amide structured PAR-1 antagonist containing structures, such as alkoxy substituted pyridyl and the like, a preparation method of the antagonist and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C1-C3 alkyl and C3-C5 cycloalkyl.
Owner:ZHEJIANG PHARMA COLLEGE

Benzo diene tetrazole compound, preparation method and application of benzo diene tetrazole compound

The invention relates to the field of drugs related to thrombotic diseases. Particularly, the invention relates to a PAR-1 antagonist with a benzo diene tetrazole structure as shown in the specification, a preparation method and an application of the PAR-1 antagonist. R1 is selected from alkyl of H and C1-C3, and a naphthenic base of C3-C5.
Owner:FOSHAN SAIWEISI MEDICINE SCI & TECH
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