The invention relates to aquatic water autonomous cruise multistage aerobic equipment. The equipment comprises a bearing driving device, an aeration device, a detection control device and a power supply storage device; the bearing driving device comprises a floating platform, driving components and a direction sensor, and the driving components are uniformly installed on the edge of the floating platform; the direction senor is installed on the floating platform and electrically connected with the detection control device; the aeration device comprises an integration box, a miniature oxygen generator, an air pump, a water pump, a water pump pipe, a return pipe, a connecting shaft and a spray head; the integration box is installed on the upper portion of the floating platform, the integration box, the air pump and the miniature oxygen generator are connected in sequence, the water pump pipe, the return pipe and the connecting shaft penetrate through the floating platform separately, thewater pump pipe, the water pump, the integration box and the return pipe are connected in sequence in the water flow direction, and the connecting shaft is connected with the integration box; the spray head is connected with the water pump. The equipment can achieve multistage aeration according to the anoxia grade. The invention further relates to an aquatic water autonomous cruise multistage aerobic method, and belongs to the technical field of aquaculture.