The invention provides a vehicle body spatial position intelligent detection device and method and application thereof. Specifically, the information of each trolley is read through an RFID reader-writer, and then the information is compared with the information detected by a laser correlation photoelectric switch; if consistent, the detection is passed; and if inconsistent, the position and the mounting condition of a coating workpiece on the transport trolley along the vertical direction can be obtained through the triggering condition of the n laser correlation photoelectric switches; the position of the coating workpiece in the horizontal direction can be obtained through the triggering conditions of m proximity switches, meanwhile, an alarm is given, and a conveying chain of the section is stopped, thus facilitating confirmation by the production personnel, and preventing waste of manpower, energy and the like caused by collision, scrappage and re-spraying due to poor workpiece feeding or poor hanging tool flowing into coating; compared with a purely-used visual system, the device is simple, good in reliability, high in flexibility, low in cost and convenient to maintain; theplurality of proximity switches are arranged on the transport line, multi-point detection can be achieved, and the transverse fault-tolerant capacity is high.