Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating moist tetter, dermatitis and psoriasis

A technology of berberine and psoriasis, which is applied in the field of pharmaceutical application of 13-hexylberberine hydrochloride and 13-hexylpalmatine hydrochloride to treat eczema, dermatitis and psoriasis, to achieve the inflammation and activity of psoriasis Effective in proliferative skin lesions, avoiding adverse consequences, and eliminating inflammatory reactions

A technology of berberine and psoriasis, which is applied in the field of pharmaceutical application of 13-hexylberberine hydrochloride and 13-hexylpalmatine hydrochloride to treat eczema, dermatitis and psoriasis, to achieve the inflammation and activity of psoriasis Effective in proliferative skin lesions, avoiding adverse consequences, and eliminating inflammatory reactions

CN100441183CInactive Publication Date: 2008-12-10CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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  • Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating moist tetter, dermatitis and psoriasis
  • Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating moist tetter, dermatitis and psoriasis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of embodiment one gel

[0018] Weigh:

[0019] Compound HB-13 or HP-13 0.2~2g

[0020] Surfactant 0.5~1g

[0021] Absolute ethanol 5~20ml

[0022] Propanethanol 10~20g

[0023] Carpopol 940 0.5~2g

[0024] Appropriate amount of triethanolamine

[0025] Add distilled water to 100g

[0026] The above formula is prepared into external gel medicine by gel conventional method.

Embodiment 2

[0027] The preparation of embodiment two cream

[0028] Weigh:

[0029] Compound HB-13 or HP-13 0.5~2g Glycerin 5~10g

[0030] Cetyl alcohol 6~8g Anhydrous ethanol Appropriate amount

[0031] White petrolatum 8~10g Ethyl ester 0.1g

[0032] Liquid paraffin 8~19g Monoglyceride 2~5g

[0033] Polyoxyethylene (40) stearate 2~5g Distilled water added to 100g

[0034] Above formula is made o / w cream medicine by cream routine operation.

[0035] How to use: Use the above gel and cream to apply an appropriate amount on the affected parts of eczema and dermatitis skin infections.

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Abstract

The present invention relates to compound 13-hexyl berberine hydrochloride and its congener 13-hexyl palmatine hydrochloride to prepare external skin anti-allergic, inflammatory, eczema, dermatitis and other skin diseases and anti-immune, inflammatory and proliferative drugs Uses of psoriasis medications. At the same time, because of its antibacterial activity, it also has a good therapeutic effect on eczema and dermatitis associated with infection. The external application of cream with 13-hexylberberine hydrochloride or 13-hexylpalmatine hydrochloride as the active ingredient has similar therapeutic effect on psoriasis as that of intermediate-acting corticosteroids and chemical antipsoriatic drug tazarotene, but not It can cause adverse reactions such as corticosteroids, and its simple and compound formulations should have unique effects in the treatment of psoriasis.

Description

technical field [0001] The present invention relates to the preparation of the compound 13-hexylberberine hydrochloride (hereinafter referred to as HB-13) and its congener 13-hexylpalmatine hydrochloride (hereinafter referred to as HP-13) for external use on the skin to prevent inflammatory skin diseases such as eczema and dermatitis the use of. Background technique [0002] HB-13 molecular formula C 26 h 31 NO 4 HCl, molecular weight 457.98, has the following chemical structure: [0003] [0004] The above-mentioned HB-13 is composed of the 13th position -H in the molecule of the parent compound berberine hydrochloride (hereinafter referred to as Bo) replaced by hexyl-C 6 h 13 Substituted derivatives are obtained by reacting berberine hydrochloride with sodium borohydride dilute lye in aqueous medium to obtain dihydroberberine, and then reacting n-hexanal and dihydroberberine in acetic acid ethanol solution to generate crude hydrochloric acid 13-Hexylberberine, and...

Claims

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Application Information

Patent Timeline
10 Dec 2008
Publication
CN100441183C
IPC
A61K31/4375; A61K9/00; A61K9/06; A61P17/00; A61P17/06
Inventors
郑家润; 张崇璞