Application of S-adenyhomotype cysteine in medical preparation

A cysteine, adenosine homocysteine ​​technology, applied in antipyretics, drug combinations, pharmaceutical formulations, etc., can solve the problem of lack of research on the effect of S-adenosine homocysteine ​​on the immune system

Inactive Publication Date: 2010-01-13
NINGBO ZIYUAN PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, the effect of S-adenosylhomocysteine ​​on the immune system in vivo has not been studied

Method used

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  • Application of S-adenyhomotype cysteine in medical preparation
  • Application of S-adenyhomotype cysteine in medical preparation
  • Application of S-adenyhomotype cysteine in medical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] Experimental drugs, animals and materials

[0022] Drug name: S-adenosylhomocysteine ​​(S-(5'-Adenosyl)-L-homocysteine), MW: 384.4.

[0023] Experimental animals: Balb / c mice, C57BL / 6 mice, 6-8 weeks old, all female mice were used in the experiment, purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences. No. 003. MRL-lpr / lpr mice were imported from Japan and provided by the SPF animal room of Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Animals were kept in a clean animal room at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, with a 12-hour light / dark cycle, room temperature of 24°C, and humidity of 50-60%.

[0024] Reagent:

[0025] Pertussis toxin (PTX) and Ovalbumin (grade V) were purchased from Sigma (St.Louis, MO.USA).

[0026] Complete Freund's adjuvant (CFA) and Mycobacterium tuberculosis H37Ra were purchased from Difco (Detroit, MI, USA). MOG 35-55 was synthesized by Shanghai S...

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Abstract

A medical application of S-adenosine homocysteine in preparing immunodepressant with high effect and low poison is disclosed.

Description

technical field [0001] The invention relates to the transfer of methyl groups to other substances by S-adenosylmethionine under the action of methyltransferases in the process of amino acid metabolism in organisms, and participates in the production of various important biologically active substances containing methyl groups such as proteins and lipids and nucleic acids. More specifically, S-adenosylmethionine in the body is transformed into S-adenosylhomocysteine ​​(S-(5'-Adenosyl)-L-homocysteine, AdoHcy) after providing a methyl group through the above reaction, and S -Adenosylhomocysteine ​​is a powerful inhibitor of S-adenosylmethionine-dependent transmethylation reactions. Background technique [0002] In the process of amino acid metabolism in organisms, S-adenosylmethionine transfers the methyl group to other substances under the action of methyltransferase, and participates in the production of a variety of important biologically active substances containing methyl ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7076A61P37/06A61P29/00A61P43/00
Inventor 左建平付云峰
Owner NINGBO ZIYUAN PHARMA INC
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