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Method for preparing Danhong injection, and products thereof

A technology for Danhong injection and injection, which is applied in the field of injection preparation and injection preparation, can solve the problems of waste of manpower, financial resources and resources, low product qualification rate, and large difference in the content of active ingredients, and achieve effective ingredients. The effect of accurate content, simple quality control and shortened production cycle

Inactive Publication Date: 2007-07-25
厦门国宇知识产权研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This makes the content of active ingredients in different batches of related preparations produced by different manufacturers across the country only with prescription quantities of salvia miltiorrhiza and safflower medicinal materials vary greatly, resulting in greater difficulty in product quality control and low product qualification rates
Some manufacturers scrapped the products in batches due to unqualified detection of active ingredients in the products, resulting in a great waste of manpower, financial resources and resources; some even simply added index ingredients to the products because of unqualified products, such as Danshensu, protocatechualdehyde, rutin, etc., thus affecting the superiority of natural medicines as a system with a fixed ratio of components to exert the overall curative effect, and ultimately affecting the stable performance of clinical curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1. Take 7.5 kg of Danshen decoction pieces, add 60% ethanol to cover the surface of the decoction pieces, soak in a water bath (70°C) for 1 hour, install a percolator, and then use 70°C warm 60% ethanol to extract by percolation to control the liquid Speed ​​3ml / min.cm 2 . When the liquid output reaches 75L, stop the percolation, and transfer the percolation liquid to the alcohol recovery tank to recover ethanol. Transfer the liquid medicine liquid to the jacketed pot again, heat until there is no alcohol smell, add an appropriate amount of 5% gelatin solution, stir until no precipitation occurs, filter, and then use the jacketed pot to ventilate the filtrate and concentrate it to a clear liquid with a relative density of 1.10 (65°C). Paste, stop the steam, pass through a microporous membrane of 0.45 μm, and store the filtrate in a cold room at 0 to 42 ° C for subsequent use, which is the extract I (about 2.5 L);

[0019] Determination of active ingredient content in ...

Embodiment 2

[0035] 1. Take 10 kg of Danshen decoction pieces and put them in a percolation cylinder with interlayer, add 70% ethanol to cover the surface of the medicinal materials, and circulate steam through the interlayer until the liquid temperature in the cylinder reaches 70°C, soak for 1 hour in heat preservation, start percolation, add ethanol, and control percolation The flow rate is 5ml / min.cm 2 , steam and keep warm at 70°C, until the effluent reaches 80L, stop the percolation, transfer the percolation liquid to the alcohol recovery tower to recover ethanol, transfer the water medicine solution to the jacketed pot, add 5% gelatin solution, and stir until no precipitation occurs , after standing for 0.5h, filter, the filtrate is concentrated, to a clear paste with a relative density of 1.10 (65°C), filter with a 0.45 μm microporous membrane, store it in a refrigerator at 0~4°C for subsequent use, and obtain the extract I ( about 3.5L).

[0036] Measure according to the high perf...

Embodiment 3

[0041] 1. Take 7.5 kg of Danshen decoction pieces, add 50% ethanol to cover the surface of the decoction pieces, soak in a water bath (40°C) for 3 hours, install a percolator, and then use 40°C warm 50% ethanol to extract by percolation to control the liquid Speed ​​1ml / min.cm 2 . When the liquid output reaches 60L, stop the percolation, and transfer the percolation liquid to the alcohol recovery tank to recover ethanol. Transfer the liquid medicine liquid to the jacketed pot again, heat until there is no alcohol smell, add an appropriate amount of 5% gelatin solution, stir until no precipitation occurs, filter, and then use the jacketed pot to ventilate the filtrate and concentrate it to a clear liquid with a relative density of 0.60 (65°C). Paste, stop the steam, pass through a 0.45 μm microporous membrane, and store the filtrate in a 0-4°C refrigerator for later use as the extract I (about 2.0L);

[0042] Measure according to the high performance liquid chromatography of ...

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Abstract

A Chinese medicine 'Danhong injection' is prepared from red sage root and safflower through respective extracting, concentrating, removing impurities, testing the content of active components, proportional mixing, and conventionally preparing injection. Its product is also disclosed.

Description

technical field [0001] The present invention relates to a method for preparing an injection, in particular to a method for preparing an injection for treating coronary heart disease, angina pectoris and other cardiovascular diseases prepared from plant crude drugs Danshen and safflower as raw materials, and the method prepared by the method. The product belongs to the field of biomedicine. Background technique [0002] Danhong (Salvia miltiorrhiza, safflower) injection is widely used clinically in the treatment of coronary heart disease, angina pectoris, myocardial infarction, ischemic encephalopathy, cerebral thrombosis and pulmonary heart disease caused by chest pain, palpitations, crooked mouth and eyes, speech and limbs Numbness, poor activity and other diseases, all have good curative effect. The traditional preparation method is to dilute and alcohol extract the prescribed amount of Danshen medicinal material first, then mix the filter residue with the prescribed amou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/534A61K9/08A61P9/10A61P7/02
Inventor 郭东宇
Owner 厦门国宇知识产权研究有限公司
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