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Use of total flarone of lamiophlomis rotata leave-stem for preparing medicine of promoting healing of bone-fracture

A technology of fracture healing and total flavonoids, which is applied in the field of medicine, can solve the problem of no unique total flavonoids in stems and leaves, and achieve the effects of broadening the scope of clinical application, shortening the harvest cycle, and saving medicinal material resources

Inactive Publication Date: 2007-08-29
刘梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] According to the research status of Duyiwei, the main effects of Duyiwei and Duyiwei extract are promoting blood circulation, analgesic, anti-inflammation, etc. It is generally used for wound pain after surgery, bleeding, rheumatic arthralgia, metrorrhagia, dysmenorrhea, gums, etc. Swelling, pain, bleeding, etc. At present, its application in orthopedics and traumatology is limited to pain relief, and there is no literature report that it has the effect of promoting fracture healing; and it is generally believed that the main effective part of the unique medicinal material is the root, not the stem and leaf. There is also no literature report that the stems and leaves of Duyiwei can be used to replace the whole herb of Duyiwei for clinical medicinal use, so there is no report about the total flavonoids of the stems and leaves of Duyiwei in the literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 The pharmacodynamics test of the total flavonoids of stems and leaves of the unique herb promoting fracture healing

[0020] Animals: SD rats, male, weighing 180-220 g.

[0021] Medicine: the total flavonoids of stems and leaves of Duyiwei, prepared by the inventor himself, administered in two dosages of 0.1 and 0.05g / Kg. Positive control drug: Traumatology Joint Bone Tablets, produced by Dalian Traditional Chinese Medicine Factory.

[0022] Test method: Take 80 SD male adult rats, anesthetize with pentobarbital sodium, sterilize the right leg of the rat with iodine and alcohol, and cut it horizontally. Covering and bandaging, ip penicillin anti-infection, for 3 consecutive days, to create a rat fracture model. The model rats were randomly divided into 4 groups, and administered intragastrically with the following doses, once per person, for 30 consecutive days. On the 15th and 30th day after the drug, 10 rats were randomly selected from each group after an...

Embodiment 2

[0027] Example 2 Unique Stem and Leaf Total Flavone Soft Capsules for Promoting Fracture Healing

[0028] Get 3kg of total flavonoids from stems and leaves of unique herb, and get 7kg of vegetable oil in addition, mix well, use gelatin as capsule shell material, press into soft capsules, promptly make the medicine of the soft capsule dosage form containing 30% stems and leaves of unique herb extract .

Embodiment 3

[0029] Example 3 Unique Stem and Leaf Total Flavonoids Powder Injection for Promoting Fracture Healing

[0030] Take 300 g of the total flavonoids from stems and leaves of the unique herb, dissolve them in 10000 ml of water for injection, and adopt the existing powder injection freeze-drying preparation process to obtain a medicine in the form of a powder injection containing the stem and leaf extract of the unique herb.

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Abstract

The present invention discloses an application of lamiophlomis rotata stem and leaf total flavone in preparation of medicine for promoting union of fracture. Said flavone component is obtained by extracting lamiophlomis rotata stem and leaf, and the medicine containing lamiophlomis rotata stem and leaf total flavone has the actions of promoting blood circulation, stopping pain and resisting inflammation.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the new application of flavonoids in the stems and leaves of the unique herb. Background technique [0002] Duyiwei is mainly distributed in the middle, east and surrounding mountains of the Hengduan Mountains in the southwest and northwest of my country. It is often found in the sparse vegetation of alpine meadows, grassland irrigation, river beaches and alpine rocky beaches at 2700-4500 meters. Among them, the unique distribution area is the largest in the alpine meadow, and the sparse vegetation in the alpine flowstone beach is the smallest. [0003] The 184th page of Chinese Pharmacopoeia 2005 edition stipulates that unique taste is the dry whole herb of Lamiophlomis rotate (Benth.) Kudo. Medicinal parts include roots, stems and leaves. [0004] Duyiwei stem and leaf refers to the aboveground part of Duyiwei, mainly including stems and leaves. [0005] The existing patent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/00A61P19/08A61K127/00A61K135/00
Inventor 刘梅李文军
Owner 刘梅
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