Target magnetic nickel nano-medicinal preparation for inhibiting tumor cell growth and its production

A nano-drug and tumor cell technology, applied in the field of biochemical medicine, can solve problems such as Ni magnetic nanoparticles that have not yet been seen, and achieve the effect of accurate targeted drug, obvious therapeutic effect, and low development cost

Inactive Publication Date: 2007-09-05
SOUTHEAST UNIV
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  • Summary
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the preparation of monodisperse magnetic nano-drug carriers has always been a technical bottleneck, there has been no direct report on the use of Ni magnetic nanoparticles as drug carriers.

Method used

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Embodiment Construction

[0014] The targeted magnetic Ni nano-medicine preparation and the preparation method thereof provided by the present invention use surface-functionalized monodisperse magnetic nano-particle Ni as a carrier, and carry quercetin or other drugs for inhibiting tumor cell growth on the carrier surface. The particle size range of the surface-functionalized monodisperse Ni magnetic nanoparticles is 5nm-120nm. Monodisperse magnetic nanoparticles Ni are prepared by electrodeposition under electrochemical oxidation conditions; the electrolysis process is carried out in 0.1M TBA-Br-2 (tetrabutylammonium-bromide (TBA-Br) 2-propanol) propanol solution, Among them, high-purity Ni sheet is used as anode, glassy carbon is used as cathode, and magnetic nano-clusters are deposited on TBA. The deposition of magnetic nanoclusters is further improved by using a hydrothermal method, that is, heat treatment is carried out in an organic solution or water after deposition, so as to obtain a surface-fu...

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Abstract

A magnetic nano-Ni medicine with high target performance for suppressing the cells of tumor, especially the malignant tumor, is prepared through preparing the solution of the single-dispersing Ni nanoparticles with functionalized surface, ultrasonic stirring, adding it in the solution of quercetin or other medicine able to suppress the cells of tumor, and slight stirring.

Description

technical field [0001] The present invention relates to the technical field of biochemical medicine, more specifically a targeted magnetic Ni (nickel) nano-pharmaceutical preparation and a preparation method thereof. The quercetin preparation obtained by applying the present invention can be administered systemically, such as intravenously or subcutaneously. Injection, etc.; it can also be used to treat cancer through intratumoral interventional drug delivery. Background technique [0002] Tumor is one of the diseases that seriously endanger human health, and its morbidity and mortality are high. In the course of tumor treatment, the commonly used treatment methods are surgical therapy, chemotherapy, radiotherapy, biological therapy and traditional Chinese medicine therapy. Surgical therapy is mainly suitable for patients with early benign tumors or malignant tumors without spread and metastasis. The disadvantage is that it is powerless against the spread and metastasis of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K9/14A61K31/352A61P35/00
Inventor 王雪梅郭大东吴春惠李庆宁
Owner SOUTHEAST UNIV
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