Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Target magnetic nickel nano-medicinal preparation for inhibiting tumor cell growth and its production

A nano-drug and tumor cell technology, applied in the field of biochemical medicine, can solve problems such as Ni magnetic nanoparticles that have not yet been seen, and achieve the effect of accurate targeted drug, obvious therapeutic effect, and low development cost

Inactive Publication Date: 2007-09-05
SOUTHEAST UNIV
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the preparation of monodisperse magnetic nano-drug carriers has always been a technical bottleneck, there has been no direct report on the use of Ni magnetic nanoparticles as drug carriers.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] The targeted magnetic Ni nano-medicine preparation and the preparation method thereof provided by the present invention use surface-functionalized monodisperse magnetic nano-particle Ni as a carrier, and carry quercetin or other drugs for inhibiting tumor cell growth on the carrier surface. The particle size range of the surface-functionalized monodisperse Ni magnetic nanoparticles is 5nm-120nm. Monodisperse magnetic nanoparticles Ni are prepared by electrodeposition under electrochemical oxidation conditions; the electrolysis process is carried out in 0.1M TBA-Br-2 (tetrabutylammonium-bromide (TBA-Br) 2-propanol) propanol solution, Among them, high-purity Ni sheet is used as anode, glassy carbon is used as cathode, and magnetic nano-clusters are deposited on TBA. The deposition of magnetic nanoclusters is further improved by using a hydrothermal method, that is, heat treatment is carried out in an organic solution or water after deposition, so as to obtain a surface-fu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A magnetic nano-Ni medicine with high target performance for suppressing the cells of tumor, especially the malignant tumor, is prepared through preparing the solution of the single-dispersing Ni nanoparticles with functionalized surface, ultrasonic stirring, adding it in the solution of quercetin or other medicine able to suppress the cells of tumor, and slight stirring.

Description

technical field [0001] The present invention relates to the technical field of biochemical medicine, more specifically a targeted magnetic Ni (nickel) nano-pharmaceutical preparation and a preparation method thereof. The quercetin preparation obtained by applying the present invention can be administered systemically, such as intravenously or subcutaneously. Injection, etc.; it can also be used to treat cancer through intratumoral interventional drug delivery. Background technique [0002] Tumor is one of the diseases that seriously endanger human health, and its morbidity and mortality are high. In the course of tumor treatment, the commonly used treatment methods are surgical therapy, chemotherapy, radiotherapy, biological therapy and traditional Chinese medicine therapy. Surgical therapy is mainly suitable for patients with early benign tumors or malignant tumors without spread and metastasis. The disadvantage is that it is powerless against the spread and metastasis of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K9/14A61K31/352A61P35/00
Inventor 王雪梅郭大东吴春惠李庆宁
Owner SOUTHEAST UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com