Method for recovering 6-amino penicillanic acid by employing membrane

An aminopenicillic acid and membrane recovery technology, applied in the field of membrane separation, can solve the problems of unstable self-cracking, high operation and maintenance requirements, and large equipment investment.

Inactive Publication Date: 2007-09-26
BEIJING DAKING EASTERN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] 1. The concentration of residual 6-aminopenicillanic acid in the crystallization mother liquor is low, and the traditional recovery process requires large investment in equipment, high operating costs and high requirements for operation and maintenance
[0004] 2. The crystallization mother liquor contains various impurities, and a large amount of recycling chemicals will affect the quality of the final product
[0005] 3. The crystallization mother liquor contains a certain amount of organic solvent. In the recovery process of 6-aminopenicillanic acid, various traditional methods need to remove this part of the organic solvent first, and the general removal method will make the crysta

Method used

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  • Method for recovering 6-amino penicillanic acid by employing membrane

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Experimental program
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Effect test

Embodiment 1

[0031]Get 38L of 6-aminopenicillanic acid crystallization mother liquor, the mass percent concentration of 6-aminopenicillanic acid is 0.25%, add sodium hydroxide to adjust the pH value of crystallization mother liquor to 5.0, then, use a precision filter with a filtration accuracy of 5 microns The filter performs coarse filtration to remove impurity particles in the mother liquor. Adjust the temperature of the crystallization mother liquor to 1 °C. Then, add the crystallization mother liquor into the nanofiltration system equipment. Nanofiltration system equipment is an existing equipment system, which already has commercial products, which mainly include the following parts: raw material pump, circulation pump, nanofiltration host, heat exchanger and cleaning system, in which nanofiltration host is installed with nanofiltration membrane. In the present invention, the nanofiltration membrane of the nanofiltration system equipment selects the organic solvent-resistant membra...

Embodiment 2

[0033] Take 60L of 6-aminopenicillanic acid crystallization mother liquor, the mass percent concentration of 6-aminopenicillanic acid is 0.39%, add potassium hydroxide to adjust the pH value of crystallization mother liquor to 8.0, and then use a precision filter with a filtration accuracy of 5 microns The filter performs coarse filtration to remove impurity particles in the mother liquor. Adjust the temperature of the crystallization mother liquor to 10°C. Then, add the crystallization mother liquor into the nanofiltration system equipment. Nanofiltration system equipment is an existing equipment system, which already has commercial products, which mainly include the following parts: raw material pump, circulation pump, nanofiltration host, heat exchanger and cleaning system, in which nanofiltration host is installed with nanofiltration membrane. In this embodiment, the nanofiltration membrane of the nanofiltration system equipment is selected from American Koch Company's o...

Embodiment 3

[0035] Get 50L of 6-aminopenicillanic acid crystallization mother liquor, the mass percent concentration of 6-aminopenicillanic acid is 0.51%, add sodium hydroxide to adjust the pH value of crystallization mother liquor to 6.5, then, use a precision filter with a filtration accuracy of 5 microns The filter performs coarse filtration to remove impurity particles in the mother liquor. Adjust the temperature of the crystallization mother liquor to 5°C. Then, add the crystallization mother liquor into the nanofiltration system equipment. Nanofiltration system equipment is an existing equipment system, which already has commercial products, which mainly include the following parts: raw material pump, circulation pump, nanofiltration host, heat exchanger and cleaning system, in which nanofiltration host is installed with nanofiltration membrane. In this embodiment, the nanofiltration membrane of the nanofiltration system equipment is selected from American Koch Company's organic s...

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Abstract

The invention discloses a recycling method of 6-amino penicillanic acid through film, which comprises the following steps: adjusting pH value of crystal mother liquid with 6-amino penicillanic acid to 5.0-8.5; proceeding rough filter; adding mother liquid into nano-filtering system; separating through nano-filtering film; obtaining the condensate and dislysate with condensing times at 5-20; adopting the organic solvent tolerant film with stop molecular weight at 5-800 at 1-10 deg.c under 15-40bar; washing the nano-filtering system.

Description

technical field [0001] The invention relates to a method for recovering 6-aminopenicillanic acid in the field of membrane separation, in particular to a process for producing semi-synthetic penicillin through mother nuclei, directly applying membranes to recover 6-aminopenicillane from crystallization mother liquor sour method. Background technique [0002] Penicillin is the most common antibiotic with high efficiency and low toxicity that was first discovered and clinically applied. With the extensive use of penicillin, the phenomenon of bacterial resistance is becoming more and more serious. Secondly, benzyl penicillin, which is widely used clinically, is not stable to acid, has a low antibacterial spectrum, and easily causes allergic reactions, etc., all of which limit its application. Until the early 1960s, the discovery and production of 6-aminopenicillanic acid, the mother nucleus of penicillin, provided a material basis for extensive structural modification of penic...

Claims

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Application Information

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IPC IPC(8): C07D499/42B01D61/00
Inventor 温建波
Owner BEIJING DAKING EASTERN TECH
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