Method for recovering 6-amino penicillanic acid by employing membrane

Abstract

The invention discloses a recycling method of 6-amino penicillanic acid through film, which comprises the following steps: adjusting pH value of crystal mother liquid with 6-amino penicillanic acid to 5.0-8.5; proceeding rough filter; adding mother liquid into nano-filtering system; separating through nano-filtering film; obtaining the condensate and dislysate with condensing times at 5-20; adopting the organic solvent tolerant film with stop molecular weight at 5-800 at 1-10 deg.c under 15-40bar; washing the nano-filtering system.

Description

technical field [0001] The invention relates to a method for recovering 6-aminopenicillanic acid in the field of membrane separation, in particular to a process for producing semi-synthetic penicillin through mother nuclei, directly applying membranes to recover 6-aminopenicillane from crystallization mother liquor sour method. Background technique [0002] Penicillin is the most common antibiotic with high efficiency and low toxicity that was first discovered and clinically applied. With the extensive use of penicillin, the phenomenon of bacterial resistance is becoming more and more serious. Secondly, benzyl penicillin, which is widely used clinically, is not stable to acid, has a low antibacterial spectrum, and easily causes allergic reactions, etc., all of which limit its application. Until the early 1960s, the discovery and production of 6-aminopenicillanic acid, the mother nucleus of penicillin, provided a material basis for extensive structural modification of penic...

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Problems solved by technology

[0003] 1. The concentration of residual 6-aminopenicillanic acid in the crystallization mother liquor is low, and the traditional recovery process requires large investment in equipment, high operating costs and high requirements for operation and maintenance

[0004] 2. The crystallization mother liquor contains various impurities, and a large amount of recycling chemicals will affect the quality of the final product

[0005] 3. The crystallization mother liquor contains a certain amount of organic solvent. In the recovery process of 6-aminopenicillanic acid, various traditional methods need to remove this part of the organic solvent first, and the general removal method will make the crystallization The mother liquor is warmed up, and this process will accelerate the unstable self-cleavage of 6-aminopenicillanic acid, which will seriously affect the yield and the final quality of the product

[0007] This shows that the above-mentioned existing method for reclaiming 6-aminopenicillanic acid obviously still has inconvenience and defects in use, and needs to be further improved urgently.

In order to solve the problems existing in the method of recovering 6-aminopenicillanic acid, the relevant manufacturers have tried their best to find a solution, but no suitable design has been developed for a long time. This is obviously what the relevant industry is eager to solve. question

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