Method for preparing Cefquinome sulfate of antibiotics of animal

A technology of cefquinome sulfate and cefquinome sulfate, which is applied in the field of preparation of raw material cefquinome sulfate, can solve the problems of increased drug resistance of pathogenic bacteria, poor therapeutic effect, threat to human health, etc., and achieves good therapeutic effect, low toxicity, Effects of Avoiding the Rising Problem of Cross-Resistant Zoonotic Diseases

Inactive Publication Date: 2007-10-10
蒋春茂
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Problems solved by technology

For the prevention and treatment of these two types of diseases, in addition to good feeding and management, antibiotic treatment is an important measure. However, due to the irrational use of drugs, the drug resistance of pathogenic bacteria is gradually increasing, and farmers have to increase the dosage and frequency of medication. , so as to

Method used

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  • Method for preparing Cefquinome sulfate of antibiotics of animal
  • Method for preparing Cefquinome sulfate of antibiotics of animal

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Embodiment 1

[0010] Example 1: Step 1, 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy -8-oxo-5-thio-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-5,6,7,8-tetrahydroquinoline hydroiodide ( The synthetic method of cefquinoxime dihydroiodide) is as follows: add 98 grams (0.2mol) cefotaxime and 1800ml dichloromethane in the reaction flask, stir and cool to below 5 ℃ under the ice bath, then slowly add 5 , 6,7,8-tetrahydroquinoline, keep it below 5°C, add 200ml iodotrimethylsilane dropwise, after the addition, heat up and reflux for 3 hours, cool to below 5°C, start to drop 400ml of the mixed solution ( Composed of 45% hydroiodic acid: distilled water: ethanol = 1:1:3). A light yellow precipitate of dihydroiodide was precipitated, which was allowed to stand at 0°C for 4 hours, and the precipitate was filtered off. Wash with 100ml×2 dichloromethane and 100ml acetone, dry in air to obtain 103g of 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxy Imino)acetyl]amino]...

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Abstract

This invention discloses a method for preparing cefquinome sulfate as an animal antibiotic. The method comprises: synthesizing 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazole)(methoxyimino)acetyl]amino]-2-carboxyl-8-O-5-S-1-diazabicyclo[4.2.0]-2-octene-3-yl]methyl]-5,6,7,8-tetrahydroquinoline hydroiodate cefquinome dihydroiodate, and then preparing cefquinome sulfate.

Description

technical field [0001] The invention relates to a preparation method of cefquinome sulfate, a raw material of animal antibiotics. Background technique [0002] With the continuous promotion of intensive farming and people's demand for livestock products, the stock of pigs, cattle and other livestock in my country has continued to increase, and the difficulty of disease prevention and control has also increased. Livestock respiratory infection and dairy cow mastitis are the two diseases with the highest morbidity, the most difficult treatment and the most serious economic loss in large livestock breeding. For the prevention and treatment of these two types of diseases, in addition to good feeding and management, antibiotic treatment is an important measure. However, due to the irrational use of drugs, the drug resistance of pathogenic bacteria is gradually increasing, and farmers have to increase the dosage and frequency of medication. , so as to fall into the "vicious circl...

Claims

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Application Information

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IPC IPC(8): C07D501/46
Inventor 蒋春茂陆广富李勇军肖文华金礼琴葛竹兴
Owner 蒋春茂
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