Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing Cefquinome sulfate of antibiotics of animal

A technology of cefquinome sulfate and cefquinome sulfate, which is applied in the field of preparation of raw material cefquinome sulfate, can solve the problems of increased drug resistance of pathogenic bacteria, poor therapeutic effect, threat to human health, etc., and achieves good therapeutic effect, low toxicity, Effects of Avoiding the Rising Problem of Cross-Resistant Zoonotic Diseases

Inactive Publication Date: 2007-10-10
蒋春茂
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the prevention and treatment of these two types of diseases, in addition to good feeding and management, antibiotic treatment is an important measure. However, due to the irrational use of drugs, the drug resistance of pathogenic bacteria is gradually increasing, and farmers have to increase the dosage and frequency of medication. , so as to fall into the "vicious circle" of antibiotics, not only the treatment effect is getting worse and worse, but also the residual amount of antibiotics in meat and milk is increased, which finally poses a serious threat to human health. Low-residue animal-specific antibiotics are the top priority of current veterinary drug research and development

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing Cefquinome sulfate of antibiotics of animal
  • Method for preparing Cefquinome sulfate of antibiotics of animal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1: Step 1, 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy -8-oxo-5-thio-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-5,6,7,8-tetrahydroquinoline hydroiodide ( The synthetic method of cefquinoxime dihydroiodide) is as follows: add 98 grams (0.2mol) cefotaxime and 1800ml dichloromethane in the reaction flask, stir and cool to below 5 ℃ under the ice bath, then slowly add 5 , 6,7,8-tetrahydroquinoline, keep it below 5°C, add 200ml iodotrimethylsilane dropwise, after the addition, heat up and reflux for 3 hours, cool to below 5°C, start to drop 400ml of the mixed solution ( Composed of 45% hydroiodic acid: distilled water: ethanol = 1:1:3). A light yellow precipitate of dihydroiodide was precipitated, which was allowed to stand at 0°C for 4 hours, and the precipitate was filtered off. Wash with 100ml×2 dichloromethane and 100ml acetone, dry in air to obtain 103g of 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxy Imino)acetyl]amino]...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

This invention discloses a method for preparing cefquinome sulfate as an animal antibiotic. The method comprises: synthesizing 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazole)(methoxyimino)acetyl]amino]-2-carboxyl-8-O-5-S-1-diazabicyclo[4.2.0]-2-octene-3-yl]methyl]-5,6,7,8-tetrahydroquinoline hydroiodate cefquinome dihydroiodate, and then preparing cefquinome sulfate.

Description

technical field [0001] The invention relates to a preparation method of cefquinome sulfate, a raw material of animal antibiotics. Background technique [0002] With the continuous promotion of intensive farming and people's demand for livestock products, the stock of pigs, cattle and other livestock in my country has continued to increase, and the difficulty of disease prevention and control has also increased. Livestock respiratory infection and dairy cow mastitis are the two diseases with the highest morbidity, the most difficult treatment and the most serious economic loss in large livestock breeding. For the prevention and treatment of these two types of diseases, in addition to good feeding and management, antibiotic treatment is an important measure. However, due to the irrational use of drugs, the drug resistance of pathogenic bacteria is gradually increasing, and farmers have to increase the dosage and frequency of medication. , so as to fall into the "vicious circl...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D501/46
Inventor 蒋春茂陆广富李勇军肖文华金礼琴葛竹兴
Owner 蒋春茂
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com