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A kind of freeze-dried powder injection and preparation method thereof

A technology of freeze-dried powder injection and freeze-dried powder injection, applied in the field of Xingnaojing freeze-dried powder injection and its preparation, to achieve the effect of ensuring storage quality

Active Publication Date: 2011-12-28
HENAN NEW CENTURY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, some commonly used traditional Chinese medicine injections in clinical practice have poor drug stability due to various reasons, and there are frequent reports of adverse reactions, so it is necessary to further research and develop.

Method used

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  • A kind of freeze-dried powder injection and preparation method thereof
  • A kind of freeze-dried powder injection and preparation method thereof
  • A kind of freeze-dried powder injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0180] a. Take the following raw drug components in parts by weight: musk 15g, turmeric 60g, gardenia 60g, borneol 1g;

[0181] b. For the above four flavors, the turmeric is crushed into coarse particles, and the volatile oil is extracted for later use; the Gardenia jasminoides is extracted with ethanol, filtered, and the extracts are combined, the ethanol is recovered, concentrated into an extract, and the pH of the extract is adjusted with HCl, boiled, cooled, Centrifuge after refrigeration, extract the centrifugate with n-butanol, combine the n-butanol extracts, recover n-butanol under reduced pressure, concentrate, and dry to obtain the gardenia extract; musk is extracted with ethanol continuous reflux, and the extract is used for later use; borneol is crushed for later use; According to the preparation method of freeze-dried powder injection, the above-mentioned substances are prepared into freeze-dried powder injection.

[0182] Embodiment 2: the preparation of freeze-d...

Embodiment 2

[0183] a. Take the following raw material drug components in parts by weight: musk 90g, turmeric 300g, gardenia 300g, borneol 6g;

[0184] b. For the above four flavors, the turmeric is crushed into coarse particles, and the volatile oil is extracted for later use; the Gardenia jasminoides is extracted with ethanol, filtered, and the extracts are combined, the ethanol is recovered, concentrated into an extract, and the pH of the extract is adjusted with HCl, boiled, cooled, Centrifuge after refrigeration, extract the centrifugate with n-butanol, combine the n-butanol extracts, recover n-butanol under reduced pressure, concentrate, and dry to obtain the gardenia extract; musk is extracted with ethanol continuous reflux, and the extract is used for later use; borneol is crushed for later use;

[0185] Take hydroxypropyl-β-cyclodextrin, add water to dissolve, take the turmeric volatile oil and add it dropwise into the hydroxypropyl-β-cyclodextrin aqueous solution to seal the ultr...

Embodiment 3

[0187] a. Take musk 37.5g, turmeric 150g, gardenia 150g, borneol 5g;

[0188] b. The above four flavors and turmeric are crushed into coarse particles, and the volatile oil is extracted for later use; Gardenia is extracted 5 times with 14 times the amount of 99.5% ethanol under reflux, each time for 1 hour, filtered, combined extracts, the filtrate is decompressed to recover ethanol, and When concentrated to 50°C, the relative density is about 1.10 to 1.25. The extract is adjusted to a pH of 1 to 4 with HCl, boiled for 3 hours, cooled, refrigerated for 36 hours, centrifuged, and the centrifuged liquid is extracted 8 times with n-butanol. Combine n-butanol extracts, recover n-butanol under reduced pressure, concentrate to an extract with a relative density of about 1.10-1.35 (50°C), and dry to obtain Gardenia jasmine extract; musk is extracted with 8 times the amount of 99.5% ethanol under reflux 6 hour, the extract is ready for use;

[0189] Take 70g of hydroxypropyl-β-cyclod...

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Abstract

The medicine of the invention relates to a Xingnaojing freeze-dried powder injection and a preparation method thereof, belonging to the field of traditional Chinese medicine pharmacy. The medicine of the invention is composed of active ingredients made from musk, turmeric, gardenia and borneol after a certain extraction process. The medicine of the invention has good stability, and the method and process are simple. The medicine of the present invention has the effects of clearing away heat and purging fire, cooling blood and detoxifying. It is mainly used for TCM syndrome differentiation of stroke (syndrome of hyperactivity of wind, phlegm and fire), hemiplegia, hemiplegia, slanted tongue, slurred or speechless speech, decreased sensation or disappearance, dizziness, sudden onset, restlessness, irritability, limb strength and urgency, and excessive phlegm And sticky; red tongue, yellow greasy fur, stringy and slippery pulse symptoms.

Description

technical field [0001] The invention relates to a Xingnaojing freeze-dried powder injection and a preparation method thereof, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Ischemic stroke, accounting for 53.6% of stroke, is mainly caused by thrombosis on the basis of cerebral atherosclerosis (ie, cerebral infarction). With the in-depth understanding of the pathophysiological process of ischemic stroke and the improvement and development of new treatment methods, the concept of "brain attack" has been paid more and more attention. Every hour of initial ischemia and brain tissue damage will rapidly increase the degree of irreversible brain damage, and more and more people realize that stroke is a disease similar to myocardial infarction that also requires emergency treatment. In recent years, based on the concept of "treatment time window", a reasonable treatment plan has been formulated within a certain period of time aft...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61P9/10A61K36/9066A61K31/7048A61K31/045A61K35/55
Inventor 叶正良李永强郑永锋李瑞明
Owner HENAN NEW CENTURY PHARMA
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