Use of bupleurum root total polyoses in the preparing of medicine for preventing and treating systematic lupus erythematosus

Abstract

The invention belong to Chinese traditional medicine field, relates to the application of bupleurum root polysaccharide for preparing medicine preventing systematic Cazenave's lupus. The invention separates polysaccharide extract from bupleurum root, the average productivity is 3.32%, and the polysaccharide content is more than 65%. It is showed by whole animal model test that the protective effect for hyper reaction and kidney injury for mice by said polysaccharide is distinctive, and it is proven that polysaccharide can prevent Cazenave's lupus syndrome. The bupleurum root polysaccharide can also be used to produce medicine preventing and treating self-immune disease.

Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicine, and relates to a new medical application of total polysaccharide of Bupleurum bupleuri. It specifically relates to the use of Bupleurum total polysaccharides in the preparation of medicines for preventing and treating systemic lupus erythematosus. Background technique:

[0002] Systemic lupus erythematosus (SLE) is an inflammatory connective tissue disease with unclear etiology. It mainly affects women and can also affect children. A multi-country and multi-center study showed that the current incidence of systemic lupus erythematosus is 12.5 / 100,000 to 39 / 100,000. SLE is generally regarded as a representative autoimmune disease, and it is a severe autoimmune disease that is refractory, recurrent, and has a high fatality rate. The phenotype of autoimmune abnormalities in SLE is highly diverse, almost involving the entire immune system, including immune tolerance defect, lymphocyte ap...

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