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Application of interleukin 2 and its derivative in preparing medicine for treating rhinitis

A derivative, interleukin technology, applied in the field of biomedicine, can solve problems such as heart toxicity, aggravated nasal congestion, and difficult treatment, and achieve the effect of relieving symptoms and signs, improving lesions, and definite curative effect

Inactive Publication Date: 2008-02-20
BEIJING FOUR RINGS BIOPHARM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main drugs for treating rhinitis and their advantages and disadvantages are as follows: (1) Antihistamines, which are absorbed quickly after oral administration, can quickly improve symptoms of nasal itching, sneezing, and runny nose, but are ineffective for nasal congestion symptoms, and have side effects such as drowsiness Larger, with some antihistamines and severe cardiotoxic side effects
(2) Nasal decongestant drugs can be applied locally or systemically. Topical drugs such as ephedrine have a quick effect and can quickly relieve nasal congestion symptoms. However, such drugs cannot be used for a long time, and usually should not exceed 4 days. Because it has the side effect of vasodilation, leading to increased nasal congestion, long-term use will inevitably cause drug-induced rhinitis, increasing the complexity of rhinitis and the difficulty of treatment
So far, there is no report on the application of interleukin 2 in the treatment of rhinitis at home and abroad

Method used

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  • Application of interleukin 2 and its derivative in preparing medicine for treating rhinitis
  • Application of interleukin 2 and its derivative in preparing medicine for treating rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] Embodiment. Anti-rhinitis animal test

[0026] 1. Purpose of the test

[0027] To observe the effect of recombinant human interleukin-2 nasal spray on animal models of allergic rhinitis, and provide pharmacological experimental basis for its clinical application.

[0028] 2. Test materials

[0029] 1. Animals: 70 clean SD rats, half male and half male, provided by the General Hospital of Nanjing Military Region, weighing 220-250 grams, animal qualification certificate number: SCXK (Su 2003-0004), raised in this laboratory for 3-3 Use after 5 days.

[0030] 2. Drugs

[0031] (1) Recombinant human interleukin-2 nasal spray. Produced by Beijing Sihuan Biopharmaceutical Co., Ltd., specification: 1 million u·ml -1 , 3ml / branch. The active ingredient is interleukin 2, which is prepared by conventional auxiliary materials and conventional operations.

[0032] (2) Berkner nasal aerosol (beclomethasone dipropionate nasal aerosol). Produced by GlaxoSmithKline Pharmaceutic...

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Abstract

The present invention discloses an application of the interleukin-2 (IL-2) and the derivatives in the preparation of the drugs for treating rhinitis and pertains to the field of biomedicine. The present invention has the advantages that: the present invention firstly uses the recombinant human interleukin-2 in the treatment of rhinitis, the results show that the interleukin-2 can obviously alleviate the symptoms and physical signs of the rhinitis, significantly alleviate the nasal lesions and have the accurate efficacy.

Description

technical field [0001] The invention relates to the application of interleukin 2 (interleukin-2) and derivatives thereof as medicines for treating rhinitis, and belongs to the field of biomedicine. Background technique [0002] Rhinitis refers to inflammation of the nasal mucosa, manifested as congestion or edema. Patients often experience symptoms such as nasal congestion, runny nose, nasal itching, throat discomfort, and coughing. Rhinitis is divided into allergic rhinitis, chronic rhinitis, chronic sinusitis, etc. The clinical symptoms of rhinitis are different, and the harm is extremely harmful. When the physiological function of the nasal cavity is affected, breathing disorders will occur, causing blood oxygen concentration to decrease, and affecting other tissues and organs. Some symptoms such as headache, dizziness, memory loss, chest pain, chest tightness, lethargy and other symptoms appear, and even serious complications such as emphysema, cor pulmonale, and asthma ...

Claims

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Application Information

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IPC IPC(8): A61K38/20A61K9/08A61K9/12A61P11/02
Inventor 汤玥程度胜朱家壁
Owner BEIJING FOUR RINGS BIOPHARM
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