Application of brown seaweed polyoses sulfate in preparing medicament for treating senile dementia

A fucoidan and sulfate technology is applied in the directions of drug combination, medical raw materials derived from algae, nervous system diseases, etc., and achieves the effects of good use effect, high safety, and small toxic and side effects.

Inactive Publication Date: 2008-04-02
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature showing the use of fucoidan sulfate in the prevention and treatment of senile dementia

Method used

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  • Application of brown seaweed polyoses sulfate in preparing medicament for treating senile dementia
  • Application of brown seaweed polyoses sulfate in preparing medicament for treating senile dementia
  • Application of brown seaweed polyoses sulfate in preparing medicament for treating senile dementia

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Experimental program
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Effect test

Embodiment 1

[0021] The preparation of embodiment 1 fucoidan sulfate ester

[0022] After crushing the seaweed, add 20 times of distilled water and boil it for extraction for 2-3 hours. The extract is filtered with diatomaceous earth. The filtrate is first dialyzed with tap water for one day, and then dialyzed with distilled water for one day. Concentrate the dialysate and add ethanol to a volume concentration of 75% precipitated, and the precipitate was dried to obtain crude fucoidan sulfate. Redissolve the crude product in water at 0.05mol / L MgCl 2 In the presence of 20% volume concentration ethanol precipitation to remove water-soluble alginate, the filtrate is dialyzed and concentrated, and the volume concentration is 75% ethanol precipitation, and after drying, the purified fucoidan sulfate is obtained. Prepare four kinds of seaweed fucoidan sulfate esters according to the above method, and its chemical composition analysis is shown in the following table:

[0023] Table 1 Analysis ...

Embodiment 2

[0025] Embodiment 2 Preparation of low molecular weight fucoidan sulfate ester F1

[0026] Take 50 g of extracted laminaria fucoidan sulfate and prepare a 1.5% aqueous solution, add 30 mM ascorbic acid and 30 mM hydrogen peroxide to the solution, and react at room temperature for 2 hours. The reaction solution was dialyzed against tap water for 2 days and distilled water for 2 days using a dialysis bag with a molecular weight cutoff of 3600 Da, and then concentrated in vacuo. The concentrate was lyophilized to obtain 30 g of low molecular weight fucoidan sulfate ester sample F1 having a molecular weight of 7 kD.

Embodiment 3

[0027] The preparation of embodiment 3 fucoidan sulfate injection

[0028] Take 100g of fucoidan sulfate, add 1000ml of water for injection, 100g of mannitol, adjust the pH value to 7.0, subpackage, and freeze-dry.

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Abstract

The invention provides a brown seaweed polysaccharide sulfate with the purpose of preventing and treating senile dementia. The brown seaweed polysaccharide sulfate of the invention can be natural polysaccharide extracts from brown algae like kelp, focus, asophyllum, laminaria japonica or chorda filum, etc, or low molecular weight sulfuric acid polysaccharide or oligosaccharide material prepared by degradation of brown seaweed polysaccharide sulfate. The product of the invention has high safety and can be taken for a long term.

Description

technical field [0001] The invention relates to a drug for preventing and treating senile dementia, in particular to the use of fucoidan sulfate in the preparation of a drug for preventing and treating senile dementia. Background technique [0002] Fucoidan sulfate is a class of sulfated polysaccharides that exist in brown algae and was first extracted from kelp palmate by Kylin in 1913 with dilute acid. Kylin separated the L-fucose after hydrolyzing the extract. He named this polysaccharide fucoidin. Now it is generally named fucoidan according to the naming principle of polysaccharides. The Chinese name is fucoidan, fucoidan, and fucoidan. , fucoidan sulfate, fucoidan or fucoidan sulfate. Now people have a relatively clear understanding of the composition of fucoidan sulfate esters. It is a type of polysaccharide with very complex chemical composition and structure. It is mainly composed of fucose and sulfate groups. Sugar, uronic acid and other ingredients. Kelp fucoid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61P25/28A61K36/03
Inventor 张全斌赵婷婷李智恩徐祖洪
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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