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Chinese medicine hemorrhoid suppository preparation method

A technology of hemorrhoid suppository and traditional Chinese medicine is applied in the field of preparation of traditional Chinese medicine hemorrhoid suppository, and achieves the effects of convenient use, exact curative effect and improved stability.

Active Publication Date: 2008-07-09
YANGTZE RIVER PHARMA GRP JIA NGSU LONGFENGTANG TRADITIONAL CHINESE MEDICINE CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention provides a method for preparing a traditional Chinese medicine hemorrhoid suppository that solves the stability problems of suppositories such as delamination, discoloration, and crystal precipitation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] 1. It is made of the following raw materials or the alcohol and water extracts of the following raw materials or the water extracts of the following raw materials as active ingredients, and its raw materials are composed of:

[0009] Sophora flavescens 160~360g Cnidium 80~180g Phellodendron 53~120g

[0010] Honeysuckle 80~180g Gallnut 53~120g Alum 27~60g

[0011] Calamine 27~60g Angelica 53~120g Licorice 27~60g;

[0012] 1. Extract the volatile oil of the above-mentioned cnidium, honeysuckle, and angelica three flavors separately or in a concentrated manner, and heat the dregs, flavescens, and licorice to reflux with alcohol and water or water alone, and the obtained extract is used as active ingredient I; liquid as the active ingredient II; gallnut was heated to reflux, and the obtained extract was used as the active ingredient III; the above-mentioned extract was concentrated, dried, pulverized, and then crushed by air flow to 180-200 mesh to obtain medicinal powder ...

Embodiment 2

[0016] 1. Same as Embodiment 1.

[0017] 2. Weigh 1405g of mixed fatty acid glyceride and 60g of lanolin, heat to melt completely, then add 0.3g of EDTA and 0.6g of sodium bisulfite, and mix well. Slowly cool until the temperature is right, add the 2 drug powders, stir to make it even, and then get the suspension.

[0018] 3. After the above-mentioned suspension medicinal liquid is sheared and dispersed by a microemulsion shearing machine, it is poured into a plug mold, and taken out after cooling. Gained suppository 1000 pieces.

[0019] Stability test results:

[0020] The suppository I that above-mentioned method is made and the suppository II that traditional method makes are carried out stability investigation simultaneously according to requirement in the appendix of Chinese Pharmacopoeia One (2005 edition), and the results are shown in the table:

[0021] Table: Stability study results

[0022] time

[0023] Body precipitation

[0...

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Abstract

The present invention discloses a preparation method of Chinese medicine haemorrhoids suppository. The following raw materials are made into the extract, condensed, dried, ground and screened, including 160 to 360g of lightyellow sophora root, 80 to 180g of common cnidium fruit, 53 to 120g of corktree bark, 80 to 180g of honeysuckle, 53 to 120g of Chinese gall, 27 to 60g of alumen, 27 to 60g of calamine, 53 to 120g of angelica and 27 to 60g of liquorice. Tween-80, EDTA and sodium bisulfite are added and evenly mixed; greasy molten medium is added to melt and evenly disperse so as to form a fixed shape. The present invention solves the instability of conventional preparation method of suppository. The present invention is used in perianal red swelling and heat pain, bloody stool and other symptoms caused by hemorrhoids (internal hemorrhoids, external hemorrhoids and mixed hemorrhoids). The present invention has the advantages of convenient use, quick effect and accurate curing effect.

Description

technical field [0001] The invention relates to a preparation method of traditional Chinese medicine hemorrhoid suppository. technical background [0002] CN1240412 discloses a traditional Chinese medicine compound preparation for treating hemorrhoids and a preparation method thereof. Long-term clinical verification shows that this suppository has an effective rate of 96.7% and a marked effect of 76.7% on inflammatory external hemorrhoids, thrombotic external hemorrhoids, internal hemorrhoids, mixed hemorrhoids, and anal itching, which is superior to similar hemorrhoid suppositories. Since the suppository in the above-mentioned patent is prepared according to the common suppository preparation method, there are problems such as delamination, discoloration, and crystal precipitation on the surface during the stability inspection period, which affects its storage and use to a certain extent. Contents of the invention [0003] The invention provides a preparation method of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/02A61P9/14A61K33/06A61K33/30A61K35/64
Inventor 孙田江陆宏国顾孝红吴沉张绍林
Owner YANGTZE RIVER PHARMA GRP JIA NGSU LONGFENGTANG TRADITIONAL CHINESE MEDICINE CO LTD
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