Medicinal box of GSA for producing technetium-99m mark and method for producing the same

Abstract

The invention relates to a kit which is used for preparing <99m> Tc-GSA. Weight ratio of a reducing agent of the kit: a GSA ligand: adjuvant is 0.01-0.2:2-8:0.05-2; the reducing agent is a routine chemical reagent which can reduce <99m> Tc <7+> (<99m> TcO4<->) to <99m> Tc <5+>. The invention also relates to a preparation method of the kit. In the preparation of <99m> Tc-GSA, the kit of the invention has the advantages of simple method, high mark rate, excellent biological properties of prepared <99m> Tc-GSA and low use cost, and facilitates wide clinical application.

Description

A kind of medicine kit for preparing technetium-99m-labeled GSA and preparation method thereof technical field The present invention relates to a lyophilized kit for preparing GSA of technetium-99m (99mTc), and a preparation method of the kit. Background technique The plasma asialoglycoprotein receptor (ASGP-R) exists on the mammalian hepatocyte membrane, which is a specific site that mediates the removal of asialoglycoprotein (ASGP) in the blood by the liver. ASGP-R can reflect effective hepatocyte function to a certain extent. When liver damage diseases such as hepatitis, cirrhosis or liver cancer occur, its quantity and activity are damaged. Therefore, quantitative analysis of ASGP-R is helpful in Better judgement of remaining liver function before surgery. Among the many methods for evaluating liver function, liver imaging methods have developed rapidly. In particular, single photon emission computer tomography (SPECT) is used in nuclear medicine to dynamically observ...

AI Technical Summary

Problems solved by technology

This research is still blank in our country, mainly due to the lack of ASGPR imaging agents for nuclear medicine imaging, especially the lack of freeze-dried kits for ASGPR imaging agents that can be used clinically, are easy to use, and are easy to promote.