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Preservative composition for ophthalmic use

A composition and ophthalmology technology, applied in the direction of drug combination, drug delivery, medical preparations of non-active ingredients, etc., can solve the problems of irritation and strong oxidation

Inactive Publication Date: 2008-07-16
SANTEN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is generally believed that when hypochlorite is decomposed, chlorine dioxide with strong oxidation effect is produced, which is irritating to eyes, skin, trachea, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0052] 1. Test for inhibiting chlorine dioxide formation

[0053] (1) Preparation of samples

[0054] Test solution 1

[0055] Dissolve 7 mg of hypochlorite, 500 mg of creatinine and 20 mg of sodium hydrogen phosphate in about 80 mL of purified water, adjust the pH to 7.0 with dilute hydrochloric acid or sodium hydroxide, and use purified water to make the total amount 100 mL to obtain test solution 1.

[0056] Test solution 2~6

[0057]Except using 5 mg geraniol, 200 mg glucose, 2 g mannitol, 100 mg polysorbate 80, and 10 mg oxyquinoline sulfate instead of 500 mg creatinine in test solution 1, perform the same operation as test solution 1 to obtain a test solution 2~6.

[0058] Test solution 7

[0059] Mix 140mg of d-α-tocopherol acetate and 100mg of polysorbate 80, then add 7mg of hypochlorite, 20mg of sodium hydrogen phosphate and about 80mL of purified water, dissolve, and adjust the pH to 7.0 with dilute hydrochloric acid or sodium hydroxide , and the total amount wa...

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PUM

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Abstract

The object of the present invention is to suppress the production of chlorine dioxide in ophthalmic liquid preparations containing hypochlorite. The ophthalmic liquid preparation containing the ophthalmic antiseptic composition can inhibit the generation of chlorine dioxide, so it is excellent in safety and can maintain the antiseptic effect for a long time, wherein the ophthalmic antiseptic composition is composed of hypochlorite and selected from the following 1 ) to at least one stabilizer in 7). 1) Creatinine, 2) Geraniol, 3) Glucose, 4) Tocopheryl Acetate, 5) Oxyquinoline Sulfate, 6) Sugar Alcohol, 7) Polyoxyethylene Sorbitan Fatty Acid Ester.

Description

technical field [0001] The present invention relates to an ophthalmic antiseptic composition composed of hypochlorite and its stabilizer, and an ophthalmic liquid preparation containing the composition. Background technique [0002] Eye drops are applied directly to the sensitive organs of the human body such as the eyes. In addition, contact lenses are also used in the environment of direct contact with the eyes. Therefore, in terms of safety, it is necessary to pay attention to the compounding ingredients of eye drops or contact lens preservation solutions, and in particular eye irritation and side effects must be considered. [0003] As antiseptic ingredients of eye drops, for example, benzalkonium chloride, benzethonium chloride, sorbic acid, etc. are being used, and as antiseptic ingredients of contact lens preservation solutions, for example, polyhexamethylene biguanide (PHMB), POLYQUAD, Hydrogen peroxide, PURITE (stabilized chlorine dioxide), etc. [0004] However, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K47/10A61K47/22A61K47/26A61K47/34
CPCA61K9/0048A61K47/10A61K47/183A61K47/22A61K47/26A61P27/02A61K47/02A61K47/34A61K9/08
Inventor 高田浩一木村章男桶本美纪子
Owner SANTEN PHARMA CO LTD