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Preparing method for extracting medicinal evodia alkaloid by ultrasound

A technology for Evodia and alkaloids, which is applied in the field of extraction of Evodia alkaloids by ultrasonic technology, can solve the problems of large solvent consumption, complicated operation and the like, and achieves the effects of high production efficiency, short production cycle and not easy to damage.

Inactive Publication Date: 2008-07-23
GUANGZHOU HANFANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But this technique is only the extraction technique of a kind of analysis method, and what investigate also is only the effect of cold soaking of different solvents, only disclosed the ultrasonic technique that does not use ethyl acetate as solvent, and it adopts up to 45 times of ethyl acetate to extract, The solvent consumption is large, and the operation is cumbersome

Method used

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  • Preparing method for extracting medicinal evodia alkaloid by ultrasound
  • Preparing method for extracting medicinal evodia alkaloid by ultrasound
  • Preparing method for extracting medicinal evodia alkaloid by ultrasound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 The selection of extraction process conditions

[0024] (1) Effect of extraction solvent on the extraction rate of total alkaloids, evodiamine and evodiamine from Evodia rutaecarpa

[0025] Experimental method: Take 700 grams of Evodia rutaecarpa powder that has been crushed through a 10-mesh sieve, put it in an ultrasonic extractor, add different extraction solvents, the weight-to-volume ratio of medicinal materials and solvents is 1:15, soak for 30 minutes, ultrasonic frequency 26kHz, extraction temperature 60°C, extraction time 40min, the extract after ultrasonic extraction is filtered or centrifuged, the supernatant is concentrated to obtain a thick paste, and the thick paste is dried under reduced pressure to obtain the total alkaloids of Evodia rutaecarpa. Calculate the extraction rate of evodiamine and evodiamine respectively. 10 batches of tests were carried out for each solvent, and the average value of each 10 batches was taken, and the results a...

Embodiment 2

[0043] Take 700 grams of Evodia rutaecarpa powder crushed through a 10-mesh sieve, put it in an ultrasonic extractor, the ethanol concentration is 95%, the weight-to-volume ratio of the medicinal material and the solvent is 1:15, soak for 30min, the ultrasonic frequency is 26kHz, and the extraction temperature is 60°C. After 40 minutes, the extract after ultrasonic extraction was filtered or centrifuged, and the supernatant was concentrated to obtain a thick paste, which was dried under reduced pressure to obtain 138.6 g of total alkaloids in Evodia rutaecarpa, with a yield of 19.8%; the content of evodiamine was 0.88 %, the extraction rate is 78.9%; the content of evodiamine is 0.84%, and the extraction rate is 79.9%.

Embodiment 3

[0045] As shown in Example 2, the difference is: the particle size of the medicinal material in Example 2 is 10 mesh, and the particle size of the medicinal material in Example 3 is 30 mesh. At this time, the total alkaloids of Evodia rutaecarpa is 162.4g, and the yield is 23.2%; The content of evodiamine is 0.80%, and the extraction rate is 80.1%; the content of evodiamine is 0.73%, and the extraction rate is 81.3%.

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Abstract

The invention discloses a preparation method for extracting evodia rutatecarpa alkaloid by an ultrasonically aided method, relating to an ultrasonic extraction method taking evodia rutatecarpa as raw material, which is that: evodia rutatecarpa medical material is ground to coarse powder which is then put in an ultrasonic extraction apparatus; ethanol solution is used as solvent and the w / v (weight-to-volume ratio) of the evodia rutatecarpa medical material and the solvent is 1:10-1:30; the coarse powder is soaked in the solvent for 30 min-60 min, and then extracted for 30-120 min under the conditions of 20-70 kHz of ultrasonic frequency and 20-70 DEG C of temperature, and then discharged and filtrated; the obtained filtrate is vacuum-filtered or centrifugalized; the obtained clear liquid is condensed and the solvent is reclaimed so as to get thick paste which is then dried; thus the evodia rutatecarpa alkaloid is obtained. The preparation method of the invention has the advantages of short extraction time and production cycle, high production efficiency, low extraction temperature, high yield of total alkaloids of evodia rutatecarpa, high extraction rate of evodiamine and rutaecarpine, suitability for industrialized mass production, etc.

Description

technical field [0001] The invention relates to a method of ultrasonically extracting evodia rutaecarpa as raw material. Specifically, it relates to a method for extracting evodia alkaloids by ultrasonic technology. Background technique [0002] Evodia rutaecarpa is included in the 2005 edition of Pharmacopoeia, and it is a traditional Chinese medicinal material that has been clinically used for hundreds of years. Evodia rutaecarpa contains a variety of chemical components, among which the alkaloids of Evodia rutaecarpa are the main active ingredients. Among the alkaloids of Evodia rutaecarpa, evodiamine and subalkine are the main alkaloids. The medicinal value of Evodia rutaecarpa alkaloids has been reported in many literatures. For example, the paper "Research Progress on the Pharmacological Effects of Evodiamine" in "Chinese Journal of Traditional Chinese Medicine Information" 2005, Volume 12, No. 6 stated that Evodiamine in Evodia rutaecarpa has anti-tumor, anti-tumor, ...

Claims

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Application Information

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IPC IPC(8): A61K36/754A61P9/12
Inventor 李金华曾荣华邹小燕葛发欢周锦柯黄裕
Owner GUANGZHOU HANFANG PHARMA
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