Medicine compounds for treating rheumatoid and atrophic arthritis

A rheumatoid and arthritis technology, applied in the direction of drug combination, antipyretics, anti-inflammatory agents, etc., can solve the problems of rising, small market, no threat, etc., and achieve the effect of clear drug effect

Active Publication Date: 2008-07-30
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 2003, the national NSAIDs for rheumatism were still dominated by the COX-2 new NSAIDs, and the market share of this type of drugs further increased, among which Celebrex of Pfizer and Vioxx of Merck occupied the NSAID market share. Among the slow-acting drugs, Suzhou Changzheng-Xinkai’s Aruva (leflunomide) has not been on the market for a long time, but its market share has risen rapidly, reaching 31.79% in 2003 The market share of the brand has become the leader in the slow-acting drug market, and the market share of other brands is very small, and it has declined compared with last year, so it cannot pose a threat to it
[0006] At present, there is no relevant report on the combination of Chinese medicinal materials turmeric and cinnamon alone in the treatment of rheumatism and rheumatoid arthritis.

Method used

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  • Medicine compounds for treating rheumatoid and atrophic arthritis
  • Medicine compounds for treating rheumatoid and atrophic arthritis
  • Medicine compounds for treating rheumatoid and atrophic arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of the medicine of the present invention

[0027] Turmeric 2000g Cinnamon 1000g

[0028] A total of 1000 capsules were made from the above two raw materials.

[0029] Above two flavors, turmeric is pulverized into coarse powder, and the percolation method (Appendix 10 of Chinese Pharmacopoeia 2005 edition) is used as solvent under the item of liquid extract and extract, and 70% ethanol is used as solvent, and percolation is carried out after soaking for half an hour, until the filtrate reaches 12000ml, stop the diafiltration, the filtrate is decompressed to recover ethanol, and concentrated to a clear paste with a relative density of 1.35-1.38 (60 ° C); cinnamon is cut into coarse particles, 5 times the amount of water is added, and steam distillation is extracted for 5 hours, and the volatile oil is collected. The extract and volatile oil are added to polyethylene glycol 400, and soft capsules are filled to make 1,000 capsules.

Embodiment 2

[0030] Example 2 Preparation of the medicine of the present invention

[0031] Turmeric 9000g Cinnamon 1000g

[0032] A total of 1000 capsules were made from the above two raw materials.

[0033] Above two flavors, turmeric is pulverized into coarse powder, according to the percolation method (Appendix 10 of Chinese Pharmacopoeia 2005 edition) under the item of liquid extract and extract, 65% ethanol is used as solvent, and percolation is carried out after soaking for half an hour, until the filtrate reaches 12000ml, stop the diafiltration, the filtrate is decompressed to recover ethanol, and concentrated to a clear paste with a relative density of 1.35-1.38 (60 ° C); cinnamon is cut into coarse particles, 5 times the amount of water is added, and steam distillation is extracted for 5 hours, and the volatile oil is collected. The extract and volatile oil are added to polyethylene glycol 400, and soft capsules are filled to make 1,000 capsules.

Embodiment 3

[0034] Example 3 Preparation of the medicine of the present invention

[0035] Turmeric 1000g Cinnamon 9000g

[0036] Above two flavors, turmeric is pulverized into coarse powder, according to the percolation method (Appendix 10 of Chinese Pharmacopoeia in 2005 edition) under the item of liquid extract and extract, 80% ethanol is used as solvent, and percolation is carried out after soaking for half an hour, until the filtrate reaches 12000ml, stop the diafiltration, the filtrate is decompressed to recover ethanol, and concentrated to a clear paste with a relative density of 1.35-1.38 (60 ° C); cinnamon is cut into coarse particles, 5 times the amount of water is added, and steam distillation is extracted for 5 hours, and the volatile oil is collected. The extract and the volatile oil are volatilized and put into capsules to make 1000 capsules.

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Abstract

The invention provides a drug combination for curing rheumatism and rheumatoid arthritis, which is a preparation prepared by the following raw materials by weight ratio: 1-9 portions of turmeric and 9-1 portions of cassia bark. The invention also provides a preparation method of the drug combination and an application thereof. The drug combination of the invention can cure the rheumatism and rheumatoid arthritis with precise efficacy; furthermore, the turmeric and the cassia bark are used compatibly, which improves the function of lucrative synergies and provides a new choice for the clinical application.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating rheumatoid arthritis, in particular, a pharmaceutical composition prepared from turmeric and cinnamon as raw materials. It belongs to the field of traditional Chinese medicine. Background technique [0002] Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic progressive joint disease. It is a symmetrical polyarthritis that affects the joints of the hands, wrist, elbow, knee, ankle and foot. Most common. Rheumatoid arthritis can recur and persist for many years, eventually leading to joint deformity and loss of function. Rheumatoid arthritis is a worldwide disease, distributed in all races and ethnicities, with a prevalence rate of 0.4% to 1.0%. The prevalence rate is higher in blacks than in whites, and in Europeans and Americans than in Japanese. . Rheumatoid arthritis can occur at any age, but with age, its prevalence also increases, with a peak age of 40 t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/48A61K9/20A61K9/16A61K9/10A61P29/00A61P19/02A61K31/122
Inventor 赵军宁杨安东
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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