Atrial septal defect plugging device knitted by degradable material
A technology for atrial septal defect and degradable materials, which is applied in the field of atrial septal defect occluders, can solve the problems of verification, no detailed discussion of weaving materials and weaving processes, and achieve the effect of avoiding biological rejection
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Embodiment 1
[0019] A double-umbrella occluder was braided with 0.2mm-diameter poly-L-lactic acid (PLLA) monofilament, the diameter of the large disk was 18mm, and the diameter of the small disk was 12mm. The film material among them is a polyester film with a thickness of 500nm. After molding, the occluder was tested in vitro.
[0020] The experimental device is made of plexiglass, and the two closed cavities in the middle are connected by small holes. The diameter of the small hole in the middle is slightly smaller than the diameter of the waist of the occluder, which can be compared with the diameter of the interatrial septum of the heart. Use the delivery device to deliver the occluder to the small hole, release the occluder, and then fix the occluder at the small hole after deployment. Build a model, the internal liquid temperature is about 37 degrees Celsius, simulating the internal environment of the human body.
[0021] The internal liquid is a phosphate buffer solution, which i...
Embodiment 2
[0024] A double-umbrella occluder was braided with 0.2mm-diameter poly-L-lactic acid (PLLA) monofilament, the diameter of the large disk was 14mm, and the diameter of the small disk was 9mm. The film material among them is a polyester film with a thickness of 700nm. After shaping, the occluder was introduced into the body of experimental dogs through the delivery device for animal experiments.
[0025] During the experiment, the dogs grew in good condition without systemic or local complications. The tissue has good compatibility with PLLA, and no severe acute tissue reaction and toxicological reaction occurred in dogs.
[0026] Regarding the degradability, after 30 days, the animals were observed with a scanning electron microscope, and it can be found that the occluder stent has been degraded to a certain extent in the SEM photos. After 6 months, the degree of degradation increased.
Embodiment 3
[0028]A double-umbrella occluder was braided by PBO monofilament with a diameter of 0.3 mm. The diameter of the large disc was 74 mm, and the diameter of the small disc was 66 mm. Add 3 nickel-titanium memory alloy wires with a diameter of 0.2mm on the outside, so that the quality of the memory alloy wires only accounts for 9.45% of the total mass of the occluder, less than 30%. Its role is to enhance resilience and grip. The film material among them is a polyester film with a thickness of 700nm. After heat setting, the occluder was introduced into the body of experimental dogs through the delivery device for animal experiments.
[0029] During the experiment, the dog's tissue had good compatibility with PBO, and no complications occurred. This kind of occluder is firmly clamped on the defect site and will not fall off easily.
[0030] After 30 days, the animals were observed under a scanning electron microscope, and it can be found that the PBO part of the occluder stent h...
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