Suppository and preparation thereof

A technology for suppositories and senility, which is applied in the field of traditional Chinese medicine suppositories and their preparation, which can solve the problems of increasing the cost of unit preparations, and achieve the effect of solving the relatively long melting time limit, avoiding adverse effects, and simplifying the production process

Active Publication Date: 2008-08-20

HAINAN BIKAI PHARM CO LTD

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AI-Extracted Technical Summary

Problems solved by technology

Although, after adding Pluronic-188, after properly adjusting the ratio, except that the melting time limit is slightly extended, the above-mentioned problems can b...

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Abstract

The invention relates to a suppository, belonging to a field of drug preparation. Compared with conventional suppository, the suppository provided by the invention can change the appearance of drug preparation well, and has good inclusion action for odor, moreover the stability and therapeutic effect of drug preparation are improved obviously.

Application Domain

AntimycoticsHydroxy compound active ingredients +4

Technology Topic

SuppositoryDrugs preparations +5

Image

Examples

Experimental program(5)

Example Embodiment

[0061] Comparative Example 1

[0062] This example briefly describes the suppository prepared by the preparation method after adding Tween-61:

[0063] Mix 82 g of zedoary turmeric oil with 75 g of polysorbate 80, and dissolve 75 g of borneol with an appropriate amount of ethanol and mix with the above-mentioned oil solution.

[0064] Take 1241g of polyoxyethylene stearate and 310g of Spitwet-61, put it on a water bath and heat to melt, add the above-mentioned liquid medicine, stir evenly, fill, take out after cooling, make 1000 tablets, and get it. Labeled as suppository A.

Example Embodiment

[0065] Comparative Example 2

[0066] This example briefly describes the suppository prepared by the preparation method after adding Carbomer P40:

[0067] Mix 82 g of zedoary turmeric oil with 75 g of polysorbate 80, and dissolve 75 g of borneol with an appropriate amount of ethanol and mix with the above-mentioned oil solution.

[0068] Take 1163g of polyoxyethylene stearate and 388g of Carbomer P40, put them on a water bath and heat to melt, add the above-mentioned liquid medicine, stir evenly, fill, take out after cooling, and make 1000 tablets, which is ready. Labeled as suppository B.

Example Embodiment

[0069] Comparative Example 3

[0070] This example briefly describes the suppository prepared by the preparation method after adding Pluronic-188:

[0071] Mix 82 g of zedoary turmeric oil with 75 g of polysorbate 80, and dissolve 75 g of borneol with an appropriate amount of ethanol and mix with the above-mentioned oil solution.

[0072] Take 1303g of polyoxyethylene stearate and 248g of Pluronic (Pluronic-188), put it on a water bath and heat to melt, add the above-mentioned liquid medicine, stir evenly, fill, and take out after cooling to make 1000 tablets, which is ready to be obtained. Labeled as suppository C.

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PUM

Description & Claims & Application Information

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the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine

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