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Suppository and preparation thereof

A technology for suppositories and senility, which is applied in the field of traditional Chinese medicine suppositories and their preparation, which can solve the problems of increasing the cost of unit preparations, and achieve the effect of solving the relatively long melting time limit, avoiding adverse effects, and simplifying the production process

Active Publication Date: 2008-08-20
HAINAN BIKAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although, after adding Pluronic-188, after properly adjusting the ratio, except that the melting time limit is slightly extended, the above-mentioned problems can be overcome substantially, but the cost of the unit preparation is increased.
[0005] Therefore, prior art does not propose feasible solution to above-mentioned problem

Method used

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  • Suppository and preparation thereof
  • Suppository and preparation thereof
  • Suppository and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] In this embodiment, the suppository prepared by the preparation method after adding Tween-61 is briefly described:

[0063] Mix 82g of turmeric oil with 75g of polysorbate 80, dissolve 75g of borneol with an appropriate amount of ethanol, and mix with the above oil solution.

[0064] Take 1241g of polyoxyethylene stearate and 310g of Tushi-61, heat it on a water bath to melt, add the above liquid medicine, stir well, fill it, take it out after cooling, and make 1000 capsules. Labeled as Suppository A.

Embodiment 2

[0066] The suppository prepared by the preparation method after adding Carbomer P40 is briefly described in this embodiment:

[0067] Mix 82g of turmeric oil with 75g of polysorbate 80, dissolve 75g of borneol with an appropriate amount of ethanol, and mix with the above oil solution.

[0068] Take 1163g of polyoxyethylene stearate and 388g of carbomer P40, heat on a water bath to melt, add the above-mentioned medicinal solution, stir well, fill, take out after cooling, and make 1000 capsules. Labeled as suppository B.

Embodiment 3

[0070] The suppository prepared by the preparation method after adding Pluronic-188 is briefly described in this embodiment:

[0071] Mix 82g of turmeric oil with 75g of polysorbate 80, dissolve 75g of borneol with an appropriate amount of ethanol, and mix with the above oil solution.

[0072] Take 1303g of polyoxyethylene stearate and 248g of Pluronic (Pluronic-188), heat on a water bath to melt, add the above liquid medicine, stir well, fill it, take it out after cooling, and make 1000 capsules. Labeled as Suppository C.

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Abstract

The invention relates to a suppository, belonging to a field of drug preparation. Compared with conventional suppository, the suppository provided by the invention can change the appearance of drug preparation well, and has good inclusion action for odor, moreover the stability and therapeutic effect of drug preparation are improved obviously.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a traditional Chinese medicine suppository and a preparation method thereof. Background technique [0002] Zedoary oil is an ingredient extracted from the traditional Chinese medicine Curcuma, which has the functions of promoting blood circulation and removing blood stasis, clearing away heat and eliminating accumulation, relieving pain, removing putrefaction and promoting muscle growth. According to modern pharmacological studies, zedoary oil has broad-spectrum antibacterial microorganisms, inhibits fungi, bacteria, mycoplasma and anti-inflammation; it can improve the body's immunity, promote blood circulation and remove blood stasis, enhance blood circulation and peripheral blood cell counts on the erosion surface, and enhance phagocytes It can directly inhibit and destroy cancer cells, has obvious inhibitory effect on HPV, and can prevent the occurrence of cervical c...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/02A61K47/34A61P15/02A61P31/10A61K31/045A61K47/10A61K47/14
Inventor 陈容殷栋二康晓飞符成龙
Owner HAINAN BIKAI PHARM CO LTD
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