Application of matrimony vine and black fungus in preparing fatty liver resistant medicament

An anti-fatty liver and wolfberry technology, which is applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve the problems of liver burden and high price

Inactive Publication Date: 2008-09-24
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Effective drugs for the treatment of fatty liver currently on the market include: choline, methionine, inositol, simvastatin, etc. Although they have a good therapeutic effect on fatty liver, long-term use itself is also a burden on the liver, and the price also quite expensive

Method used

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  • Application of matrimony vine and black fungus in preparing fatty liver resistant medicament
  • Application of matrimony vine and black fungus in preparing fatty liver resistant medicament
  • Application of matrimony vine and black fungus in preparing fatty liver resistant medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0051] Embodiment (anti-fatty liver experiment)

[0052] 1.1 Animal grouping:

[0053] Divide them into 6 groups according to the random number table:

[0054] 1: Normal control group: 14+4

[0055] 2: Model control group: 15+5

[0056] 3: Simvastatin group (positive control group): 14 rats

[0057] 4: Qier granule group (large dose): 15

[0058] 5: Qier granule group (medium dose): 14

[0059] 6: Qier granule group (small dose): 15

[0060] A total of 9 rats were reserved for the normal control group and the model control group. The purpose was: after about 4 weeks of modeling, they were executed first to observe the formation of the fatty liver model, so as to determine the time required for formal modeling.

[0061] 1.2 Preparation of modeling reagents:

[0062] With reference to the literature (Liu Ming et al.: A simple and practical model of hyperlipidemia in rats. Chinese Pharmacology Pictorial, 1985, 20 (5): 199-199) and make appropriate adjustments according to ...

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Abstract

The invention belongs to the foodstuff and health product field, in particular relates to an application of the traditional Chinese medicine of medlar and blackfungus to the preparation of a drug for curing fatty liver. The invention adopts a medlar and blackfungus compound granular formulation. The fat emulsion made of fat, cholesterin, sodium taurocholate and propylthiouracil is given to rats; a fatty liver animal model is made; the function for preventing fatty liver of medlar and blackfungus is studied. The experimental results show that the medlar and the blackfungus have evident functions for preventing fatty liver and can reduce the liver weight/body mass index, the contents of serum and hepatic tissue cholesterin are decreased and the number of liver cells of steatosis is reduced. The medlar and the blackfungus can be used for preparing the drug for curing fatty liver.

Description

technical field [0001] The invention relates to the application of wolfberry fruit and black fungus in the preparation of anti-fatty liver medicine. Background technique [0002] The lipid content in the liver of normal people accounts for 2%-4% of the wet weight of the liver, of which phospholipids account for more than 50%, triglycerides (TG) account for 20%, free fatty acids (FFA) account for 20%, and cholesterol accounts for about 7%. , and the rest are cholesteryl esters. When the lipid accumulation in the liver cells exceeds 5% of the wet weight of the liver, or when more than 1 / 3 of the liver cells are fatty in each unit area in histology, it is called fatty liver (Zhang Darong. Fatty Liver. Shanghai Medicine, 1995, 4( 7): 56-57). [0003] Fatty liver refers to the disease caused by the persistent accumulation of excess fat in the liver caused by the liver itself and extrahepatic reasons. Sincerely. This disease belongs to the categories of "accumulation" and "dam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K9/16A61P1/16
Inventor 陈长勋茅仁刚金若敏
Owner SHANGHAI UNIV OF T C M
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