Molecule making for identifying liver fibrosis and hepatic cirrhosis and micro-array system plate thereof

A molecular marker, liver fibrosis technology, applied in the directions of preparations, material testing products, pharmaceutical formulas, etc. for in vivo experiments to achieve the effect of treating or slowing liver cirrhosis

Inactive Publication Date: 2008-10-01
VITA GENOMICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Although current medical protocols suggest that, to some extent, fibrosis and cirrhosis may be reversible with treatment of chronic hepatitis, there is no adequate treatment for fibrosis and cirrhosis

Method used

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  • Molecule making for identifying liver fibrosis and hepatic cirrhosis and micro-array system plate thereof
  • Molecule making for identifying liver fibrosis and hepatic cirrhosis and micro-array system plate thereof
  • Molecule making for identifying liver fibrosis and hepatic cirrhosis and micro-array system plate thereof

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Embodiment Construction

[0019] Hereinafter, preferred embodiments of the present invention will be described with reference to related drawings, wherein the same components will be described with the same reference symbols.

[0020] figure 1 A graph of 28 genes is shown for use in the present invention. Such as figure 1 As shown, a molecular marker for identifying liver fibrosis and liver cirrhosis and a microarray system board thereof provided by the present invention include at least one of the following proteins or one of the genes / genes encoding these proteins:

[0021] Albumin (ALB, albumin); Alanyl (membrane) aminopeptidase (ANPEP, alanyl[membrane]aminopeptidase); Annexin A2 (ANXA2, annexin A2); Apolipoprotein F (APOF, apolipoprotein F); like protein β (A4) precursor protein (APP, amyloid beta[A4]precursor protein); α2-glycoprotein 1, zinc-binding (AZGP 1, alpha-2-glycoprotein 1, zinc-binding); betaine homocysteine Amino acid methyltransferase (BHMT, betaine-homocysteinemethyltransferase); c...

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Abstract

The present invention provides a molecular mark for determining liver fibrosis and cirrhosis and a micro-array system board thereof. The invention at least comprises one in 28 proteins or at least comprises one in the genes encoding these proteins. Among these proteins or genes, 8 members are upper regulatory genes, 13 members are lower regulatory genes, and the rest 9 members are treating target. The invention is a molecular mark with filtering capacity to warn the generation of severe liver fibrosis or cirrhosis. The molecular mark of the invention is also a target which has latent capacity for the medicament design.

Description

technical field [0001] The invention relates to the detection of liver diseases, and in particular relates to a molecular marker for identifying liver fibrosis and liver cirrhosis and a microarray system board thereof. Background technique [0002] Many diseases include hepatitis virus infection, alcohol abuse and liver damage caused by long-term exposure to organic solvents. The result of liver damage is inflammation, hardening of tissue and even the formation of cancer. The continuous attack of liver inflammation not only triggers many biochemical events, such as immune response, secretion of cytokines and chemohormones, gangrene, activation of hepatic stellate cells and oxidative stress, but also triggers cellular and structural reorganization, as well as That is, liver fibrosis and liver cirrhosis (Marcellin et al., Discussion published in Sections 47-56 of Fibrosis and disease progression in hepatitis C in Hepatology No. 36 in 2002). [0003] Liver fibrosis describes ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/58A61K51/00
Inventor 苏春霖吴英杰
Owner VITA GENOMICS
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