Applications of hexa-gelsemicine in preparing medicament for treating chronic ache
A technology for chronic pain and inflammatory pain, which is applied in the application field of hookosin in the preparation of drugs for treating chronic pain, and achieves the effects of strong analgesic efficacy, clear industrialization prospects, and effective chronic pain.
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Embodiment 1
[0029] Analgesic Effect of Gelkinin by Subcutaneous Injection on the Back of the Neck on Formalin-Induced Chronic Pain in Mice
[0030] 1.1 Drugs and reagents:
[0031] Kelsin has been extracted, isolated and purified from the natural plant Gelkins, with a purity of >98.5% (accurately weighed Kelsin, dissolved in 1mol / l HCl, diluted with normal saline, and adjusted to pH with 1mol / l NaOH (4<pH <7), diluted with physiological saline to the solution required for each dosage group.). Morphine hydrochloride injection (10mg / ml), product of Shenyang No. 1 Pharmaceutical Factory, batch number 102090936065021. Lysine-pirin freeze-dried powder for injection (9g / bottle, the active ingredient is aspirin), Shanghai Xinya Pharmaceutical Co., Ltd., batch number H31020058. Formaldehyde solution, Tianjin Beichen Fangzheng Reagent Factory, batch number 20070828.
[0032] 1.2 Animals:
[0033] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical Universit...
Embodiment 2
[0049] The analgesic effect of kelezine subcutaneously administered to the plantar side of formalin injection on chronic pain in mice
[0050] 2.1 Drugs and reagents:
[0051] Kelsin has been extracted, isolated and purified from the natural plant Gelkins, with a purity of >98.5% (accurately weighed Kelsin, dissolved in 1mol / 1HCl, diluted with normal saline, and adjusted to pH with 1mol / l NaOH (4<pH< 7), diluted with physiological saline to the required solution of each dosage group.). Morphine hydrochloride injection (10mg / ml), product of Shenyang No. 1 Pharmaceutical Factory, batch number 102090936065021. Indomethacin freeze-dried powder injection, SIGMA company, batch number 115K0689. Formaldehyde solution, Tianjin Beichen Fangzheng Reagent Factory, batch number 20070828.
[0052] 2.2 Animals:
[0053] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. They were raised at room temperature at 25°C under a light-dark cycl...
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